MDM4
Mdm4 p53 binding protein homolog (mouse)
Synonyms:
HDMX, MDMX, MRP1
Species:
Human MDM4 (4194), Mouse Mdm4 (17248), Rat Mdm4 (304798), domestic guinea pig Mdm4 (100719525), naked mole-rat Mdm4 (101720853), Horse MDM4 (100050113), sheep MDM4 (101112914), Domestic Rabbit MDM4 (100351683), dog MDM4 (478939), domestic cat MDM4 (101082460) ...More
UniProtKB ID:
Gene ID:
- Human(4194) Summary: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
- Mouse(17248) transformed mouse 3T3 cell double minute 4
- Rat(304798) Mdm4 p53 binding protein homolog (mouse)
- domestic guinea pig(100719525) Mdm4 p53 binding protein homolog (mouse)
- naked mole-rat(101720853) Mdm4 p53 binding protein homolog (mouse)
- Horse(100050113) Mdm4 p53 binding protein homolog (mouse)
- sheep(101112914) Mdm4 p53 binding protein homolog (mouse)
- Domestic Rabbit(100351683) Mdm4 p53 binding protein homolog (mouse)
- dog(478939) Mdm4 p53 binding protein homolog (mouse)
- domestic cat(101082460) Mdm4 p53 binding protein homolog (mouse)
- chicken(419823) Mdm4 p53 binding protein homolog (mouse)
- Zebrafish(334932) transformed 3T3 cell double minute 4 homolog (mouse)
- cow(514225) Mdm4 p53 binding protein homolog (mouse)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MDM4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-phospho-MDM4 (pSer367) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MDM4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MDM4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-MDM4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot