PPP1R12A
protein phosphatase 1, regulatory subunit 12A
Synonyms:
M130, MBS, MYPT1
Species:
Human PPP1R12A (4659), Mouse Ppp1r12a (17931), Rat Ppp1r12a (116670), Zebrafish ppp1r12a (445393), Domestic Rabbit PPP1R12A (100350558), Horse PPP1R12A (100060501), naked mole-rat Ppp1r12a (101700150), dog PPP1R12A (475411), domestic guinea pig Ppp1r12a (100727982), chicken PPP1R12A (396020) ...More
UniProtKB ID:
Gene ID:
- Human(4659) Summary: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
- Mouse(17931) protein phosphatase 1, regulatory (inhibitor) subunit 12A
- Rat(116670) protein phosphatase 1, regulatory subunit 12A
- Zebrafish(445393) protein phosphatase 1, regulatory (inhibitor) subunit 12A
- Domestic Rabbit(100350558) protein phosphatase 1, regulatory subunit 12A
- Horse(100060501) protein phosphatase 1, regulatory subunit 12A
- naked mole-rat(101700150) protein phosphatase 1, regulatory subunit 12A
- dog(475411) protein phosphatase 1, regulatory subunit 12A
- domestic guinea pig(100727982) protein phosphatase 1, regulatory subunit 12A
- chicken(396020) protein phosphatase 1, regulatory subunit 12A
- cow(538606) protein phosphatase 1, regulatory subunit 12A
- domestic cat(101089624) protein phosphatase 1, regulatory subunit 12A
- sheep(641303) protein phosphatase 1, regulatory subunit 12A
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MYPT1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Phospho-PPP1R12A-T853 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-PPP1R12A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-PPP1R12A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-MYPT1 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
chicken, human
Application
immunoprecipitation (IP)
western blot
western blot