1.37028

Glycerol

anhydrous (vegetable), EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP, ACS

• Synonym(s): 1,2,3-Propanetriol, Trihydroxylpropane, Protol, Glycerin, 1,2,3-Propanetriol, Glycerin
• Linear Formula: HOCH₂CH(OH)CH₂OH
• CAS Number: 56-81-5
• Molecular Weight: 92.09
• Beilstein: 635685
• MDL number: MFCD00004722
• UNSPSC Code: 12352104
• EC Index Number: 200-289-5

Properties

• grade: ACS reagent
• Quality Level: 500
• Agency: BP; ChP; JP; Ph. Eur.; USP
• vapor density: 3.1 (vs air)
• vapor pressure: <1 mmHg ( 20 °C)
• product line: EMPROVE^® EXPERT
• Assay: ≤98.0-101.0% (calculated on anhydrous substance, alkalimetric); ≥99.5% (calculated on anhydrous substance, GC)
• form: liquid
• autoignition temp.: 698 °F
• expl. lim.: 2.6-11.3 % (v/v)
• greener alternative product characteristics: Safer Solvents and Auxiliaries; Use of Renewable Feedstocks; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• technique(s): electrophoresis: suitable
• refractive index: n20/D 1.474 (lit.)
• pH: 5 (20 °C, 100 g/L in H₂O)
• bp: 182 °C/20 mmHg (lit.)
• mp: 20 °C (lit.)
• transition temp: flash point 199 °C
• density: 1.25 g/mL (lit.)
• application(s): liquid formulation; ophthalmics; parenterals; pharma/biopharma processes; pharmaceutical
• greener alternative category: Aligned,
• storage temp.: 2-30°C
• SMILES string: OCC(O)CO
• InChI: 1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
• InChI key: PEDCQBHIVMGVHV-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is a bio-based glycerol and is aligned with the 5th principle of Green Chemistry "Safer Solvents and Auxiliaries" and 7th principle "Use of Renewable Feedstock". Click here for more details.

Application

Glycerol can be used in a wide variety of solid, semi-solid and liquid formulations, including ophthalmic, oral solid and oral liquid dosages, tablet coatings, creams and gels. It is applied for its humectant, emollient, solvent/cosolvent, viscosity increasing, and plasticizer properties.
Glycerol anhydrous (vegetable) Emprove^® Expert is low in endotoxins and bioburden, making it the right choice for your high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 390.2 °F - Pensky-Martens closed cup
• Flash Point(C): 199 °C - Pensky-Martens closed cup