46944

Fluorescein isothiocyanate–dextran

average mol wt 4,000, (FITC:Glucose = 1:250)

• Synonym(s): FITC-Dextran 4, FITC–Dextran
• CAS Number: 60842-46-8
• MDL number: MFCD00131092
• UNSPSC Code: 12352201
• NACRES: NA.32

Properties

• mol wt: average mol wt 4,000
• Quality Level: 100
• composition: (FITC:Glucose = 1:250)
• extent of labeling: ~0.004 mol/mol FITC glucose
• solubility: H₂O: 50 mg/mL, slightly hazy, orange
• storage temp.: 2-8°C

Description

Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.

FITC-dextran is used extensively in microcirculation and cell permeability research utilizing microfluorimetry. FITC-dextran has been used to study plant cell wall porosity and capillary permeability. Plasma proteins have been shown not to bind to FITC-dextran.
FITC-dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination
Fluorescein isothiocyanate–dextran (FITC-Dextran 4) is use as a fluorescent probe to study cell permeability. FITC-Dextran 4 is used with to study permeability of epithelial cell such as intestinal and renal cells in vivo.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves