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A138

Sigma-Aldrich

Aminobenztropine

solid

Synonym(s):

3-(2′-Aminobenzhydryloxy)tropane, ABT

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About This Item

Empirical Formula (Hill Notation):
C21H26N2O
CAS Number:
88097-86-3
Molecular Weight:
322.44
MDL number:
MFCD00078565
UNSPSC Code:
12352200
PubChem Substance ID:
24277819
NACRES:
NA.77

form

solid

color

white

solubility

0.1 M HCl: soluble
0.1 M NaOH: insoluble
DMSO: soluble
methanol: soluble

SMILES string

CN1C2CCC1CC(C2)OC(c3ccccc3)c4ccccc4N

InChI

1S/C21H26N2O/c1-23-16-11-12-17(23)14-18(13-16)24-21(15-7-3-2-4-8-15)19-9-5-6-10-20(19)22/h2-10,16-18,21H,11-14,22H2,1H3

InChI key

KZFDKINRISJFCO-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

Biochem/physiol Actions

High affinity muscarinic ligand that has been used for affinity purification of muscarinic cholinergic receptors.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ryuji Kato et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(10), 1093-1096 (2019-07-22)
Although the pathophysiology of carbamazepine-induced idiosyncratic or hypersensitivity reactions is unclear, they are presumed to be immune mediated, involving a complex interaction between drug metabolism and activation of the immune system. Cell stress can be caused by reactive metabolites, and
K Haga et al.
The Journal of biological chemistry, 258(22), 13575-13579 (1983-11-25)
A novel compound, 3-(2'-aminobenzhydryloxy)-tropane (ABT), and an ABT-agarose gel were synthesized and used for the purification of solubilized muscarinic receptors. ABT had a high affinity with an apparent dissociation constant (Kd) of 7 nM for the muscarinic receptors solubilized from
Takafumi Tomida et al.
The Journal of toxicological sciences, 42(5), 641-650 (2017-09-15)
The utility of HepaRG cells as an in vitro cell-based assay system for predicting drug-induced phospholipidosis (PLD) was investigated. In experiment 1, 10 PLD-positive compounds and 11 PLD-negative compounds were selected. HepaRG cells were treated with each compound for 48
Teja Klancic et al.
Biomedicines, 9(1) (2021-01-16)
Pulsed antibiotic treatment (PAT) early in life increases risk of obesity. Prebiotics can reduce fat mass and improve metabolic health. We examined if co-administering prebiotic with PAT reduces obesity risk in rat pups weaned onto a high fat/sucrose diet. Pups
Zhongyu Chiam et al.
The Science of the total environment, 688, 398-408 (2019-06-28)
Elevated levels of airborne particulate matter (PM) pose health risks to populations living in many cities worldwide. To remediate the impact of air pollution, urban greening has been increasingly explored as a possible way to remove PM from the surroundings.
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