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383R-1

Sigma-Aldrich

SOX-10 (EP268) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP268, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (383R-14)
vial of 0.5 mL concentrate (383R-15)
bottle of 1.0 mL predilute (383R-17)
vial of 1.0 mL concentrate (383R-16)
bottle of 7.0 mL predilute (383R-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

isotype

IgG

control

melanoma, skin melanocytes

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... SOX10(6663)

General description

Sry-related HMG-BOX gene 10, SOX-10, is a transcription factor involved in neural crest and peripheral nervous system development and acts as a nucleocytoplasmic shuttle protein. SOX-10 is expressed in melanocytic lineages and is a sensitive melanoma marker for conventional, and desmoplastic subtypes. In normal tissues, SOX-10 is expressed in melanocytes and myoepithelial cells.

Quality


IVD
IVD
IVD
RUO

Linkage

SOX-10 Positive Control Slides, Product No. 383S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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T A Longacre et al.
The American journal of surgical pathology, 20(12), 1489-1500 (1996-12-01)
The clinical, histologic, and immunohistologic features of 22 desmoplastic melanomas (DMM), 10 mixed desmoplastic and spindle-cell melanomas (DMM/SMM), and two cellular spindle-cell melanomas (SMM) were studied. Patients ranged in age from 35 to 91 years (mean, 67) and included 23
Robert N Kelsh
BioEssays : news and reviews in molecular, cellular and developmental biology, 28(8), 788-798 (2006-08-24)
For both vertebrate developmental and evolutionary biologists, and also for clinicians, the neural crest (NC) is a fundamental cell population. An understanding of Sox10 function in NC development is of particular significance since Sox10 mutations underlie several neurocristopathies. Surprisingly, experiments
A Robson et al.
Histopathology, 38(2), 135-140 (2001-02-24)
The histological distinction of desmoplastic melanoma from cutaneous scar tissue, particularly in the context of re-excision specimens or possible recurrence, may be very difficult. Immunostaining for S100 protein is often used to discriminate although there are little data on S100
Joe A Chorny et al.
The American Journal of dermatopathology, 24(4), 309-312 (2002-07-27)
Distinguishing desmoplastic melanoma (DM) from scar tissue on routine microscopy can be difficult, especially in re-excision specimens, and S100 immunohistochemistry has been recommended as a useful adjunct. The purpose of this study is to evaluate the extent and nature of
Frances Ivette Ramos-Herberth et al.
Journal of cutaneous pathology, 37(9), 944-952 (2010-07-27)
Sry-related HMG-BOX gene 10 (SOX10), a nuclear transcription factor that plays an important role in schwannian and melanocytic cell differentiation, has recently been shown to be a useful marker in the diagnosis of melanocytic and schwannian tumors. Fibroblasts and histiocytes
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