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P9115

Sigma-Aldrich

Protein Kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt

≥90% (HPLC), lyophilized powder

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About This Item

Empirical Formula (Hill Notation):
C53H98N20O12 · C2HF3O2
Molecular Weight:
1321.50
MDL number:
MFCD03788010
UNSPSC Code:
12352204
PubChem Substance ID:
329820342
NACRES:
NA.32

Quality Level

100

Assay

≥90% (HPLC)

form

lyophilized powder

solubility

H2O: soluble

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

InChI

1S/C53H100N20O12.C2HF3O2/c1-6-8-9-10-11-12-13-14-15-16-17-24-39(76)65-29-40(77)69-35(22-19-26-63-52(58)59)48(83)73-43(33(5)74)50(85)66-30-41(78)68-34(21-18-25-62-51(56)57)46(81)70-36(23-20-27-64-53(60)61)47(82)71-37(28-38(54)75)49(84)67-32(4)45(80)72-42(44(55)79)31(3)7-2;3-2(4,5)1(6)7/h31-37,42-43,74H,6-30H2,1-5H3,(H2,54,75)(H2,55,79)(H,65,76)(H,66,85)(H,67,84)(H,68,78)(H,69,77)(H,70,81)(H,71,82)(H,72,80)(H,73,83)(H4,56,57,62)(H4,58,59,63)(H4,60,61,64);(H,6,7)/t31-,32-,33+,34-,35-,36-,37-,42-,43-;/m0./s1

InChI key

DBHNUJXUTKVLID-UXBYPZMDSA-N

Gene Information

human ... PRKACA(5566)
mouse ... PRKACA(18747)
rat ... PRKACA(25636)

Amino Acid Sequence

Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

General description

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt inhibits the protein kinase cAMP-activated catalytic subunit-α (PRKACA). The gene encoding it is localized on human chromosome 19p13.1.

Application

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt has been used in cell culture for pharmaceutical inhibition and activation studies.

Biochem/physiol Actions

Mutations in the gene encoding protein kinase cAMP-activated catalytic subunit-α (PRKACA) have been associated with Cushing′s syndrome.
Cell permeable cAMP-dependent protein kinase (PKA) inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The gene encoding the catalytic subunit Ca of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13. 1
Kjetil Tasken
Genomics, 36.3 , 535-538 (1996)
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