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D5155

Sigma-Aldrich

Dihydrostreptomycin sesquisulfate

powder, suitable for cell culture, BioReagent

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About This Item

Linear Formula:
C21H41N7O12 · 3/2H2SO4
CAS Number:
5490-27-7
Molecular Weight:
730.71
Beilstein:
3894221
EC Number:
226-823-7
MDL number:
MFCD00070252
UNSPSC Code:
12352207
PubChem Substance ID:
24893928
NACRES:
NA.76

Product Name

Dihydrostreptomycin sesquisulfate, BioReagent, suitable for cell culture, ≥95.0% (HPLC)

product line

BioReagent

Quality Level

200

Assay

≥95.0% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Mode of action

protein synthesis | interferes

storage temp.

2-8°C

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General description

Chemical structure: aminoglycoside

Application

Dihydrostreptomycin sesquisulfate is a derivative of streptomycin used in aminoglyside uptake studies. Other studies have also used it as an electrode for a cochlear amplifier in the hair-cell bundle of lizards.

Biochem/physiol Actions

Mode of Action: Dihydrostreptomycin sesquisulfate inhibits protein synthesis at the level o the 30S ribosomal subunit and the 16s rRNA.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H361fd

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000334304
0000303624
0000303624
0000334304
0000287462

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Katy Jeannot et al.
Journal of bacteriology, 187(15), 5341-5346 (2005-07-21)
MexXY is an inducible efflux system that contributes to the natural resistance of Pseudomonas aeruginosa to antibiotics. Experiments involving real-time PCR after reverse transcription in reference strain PAO1 showed concentration-dependent induction of gene mexY by various ribosome inhibitors (e.g., chloramphenicol
Y Sasaki et al.
Epidemiology and infection, 140(11), 2074-2081 (2012-01-28)
This study determined the prevalence and antimicrobial susceptibility of Salmonella isolated from broiler flocks in Japan. Caecal dropping samples were collected from 288 broiler flocks between November 2007 and February 2010. Salmonella was prevalent in 248 (86·1%) broiler flocks. The
A C Whist et al.
Journal of dairy science, 89(12), 4649-4659 (2006-11-16)
The objective of this study was to see if introduction of a 2-yr combined selective dry-cow therapy and teat-dipping trial would reduce clinical mastitis (CM) events in 164 Norwegian dairy herds. Three different penicillin or penicillin/dihydrostreptomycin-based dry-cow treatments, and 3
K Ishihara et al.
Journal of applied microbiology, 100(1), 153-160 (2006-01-13)
To compare the antimicrobial resistance, serotypes and flagellin gene types of Campylobacter isolated from humans and food-producing animals and thereby facilitate elucidation of the origin of Campylobacter causing human infection in Japan. The MIC values of ampicillin, dihydrostreptomycin, gentamicin, erythromycin
Helen J Kennedy et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(10), 2757-2766 (2006-03-10)
There is current debate about the origin of mechanical amplification whereby outer hair cells generate force to augment the sensitivity and frequency selectivity of the mammalian cochlea. To distinguish contributions to force production from the mechanotransducer (MET) channels and somatic
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