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E-060

Supelco

17β-Estradiol solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C18H24O2
CAS Number:
Molecular Weight:
272.38
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

2-8°C

SMILES string

CC12CCC3C(CCc4cc(O)ccc34)C1CCC2O

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Gene Information

human ... ESR1(2099)

General description

A Certified Spiking Solution® suitable for use as starting material in calibrators, controls, or linearity standards for a variety of LC/MS or GC/MS applications from endocrinology to clinical and diagnostic testing.

17β-Estradiol belongs to the group of endogenous endocrine disruptors that disturb thyroid activity and function. It is also a sex hormone prescribed under the trade names Vagifem®, Estring®, Evamist, Elestrin®, Estrace®, and Estrogel® as a treatment for hypoestrogenism.

Application

The Certified Reference Material (CRM) in solution can also be used as follows:
  • Electrochemical determination of 17β-Estradiol in river water samples using a reduced graphene oxide and a metal complex porphyrin-based sensor
  • Development of a fluorescence resonance energy transfer (FRET) based aptasensor to determine 17β-Estradiol in environmental water, urine, and milk samples
  • Analysis of milk product samples to estimate 17β-Estradiol by high-performance liquid chromatography (HPLC) coupled with fluorescence detection following its solid phase extraction using graphene/multi-walled carbon nanotubes (MWCNTs)
  • Solid phase extraction of 17β-estradiol and 17α-ethinylestradiol from tap water samples using magnetic graphene oxide (GO)/γ-Fe2O3 nanoparticles for their simultaneous quantification by high-performance liquid chromatography (HPLC) combined with fluorescence detector
  • Multi-residue analysis of 17β-estradiol and 17α-ethinylestradiol in commercial pharmaceutical formulation and urine samples using hanging mercury drop electrode and screen printed carbon electrode

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Elestrin is a registered trademark of Azur Pharma
Estrace is a registered trademark of Warner Chilcott Company, LLC
Estring is a registered trademark of Pfizer Health AB
Estrogel is a registered trademark of Ascend Therapeutics, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Vagifem is a registered trademark of Novo Nordisk A/S Corp.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Michael J Gibney et al.
The American journal of clinical nutrition, 82(3), 497-503 (2005-09-13)
Metabolomics has been widely adopted in pharmacology and toxicology but is relatively new in human nutrition. The ultimate goal, to understand the effects of exogenous compounds on human metabolic regulation, is similar in all 3 fields. However, the application of
Hirotaka Ishii et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 13(4), 323-334 (2007-07-24)
It is believed that sex hormones are synthesized in the gonads and reach the brain via the blood circulation. In contrast with this view, the authors have demonstrated that sex hormones are also synthesized locally in the hippocampus and that
Shuzo Hirata et al.
Nature materials, 13(10), 938-946 (2014-09-10)
In materials showing reverse saturable absorption (RSA), the optical absorbance increases as the power of the light incident on them increases. To date, RSA has only been observed when very intense light sources, such as short-pulse lasers, are used. Here
Shel-Hwa Yeo et al.
Endocrinology, 155(8), 2986-2995 (2014-06-07)
The location and characteristics of cells within the brain that suppress GnRH neuron activity to contribute to the estrogen-negative feedback mechanism are poorly understood. Using adeno-associated virus (AAV)-mediated Cre-LoxP recombination in estrogen receptor-α (ERα) floxed mice (ERα(flox/flox)), we aimed to
Tomoko Soga et al.
Endocrinology, 155(5), 1944-1955 (2014-03-13)
Gonadotropin-inhibitory hormone (GnIH) neurons project to GnRH neurons to negatively regulate reproductive function. To fully explore the projections of the GnIH neurons, we created transgenic rats carrying an enhanced green fluorescent protein (EGFP) tagged to the GnIH promoter. With these

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