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412400

Sigma-Aldrich

IQ-1

A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation.

Synonym(s):

IQ-1, 2-(4-Acetylphenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetamide, Wnt Pathway Activator III

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10 MG
£214.00

£214.00


Availability

Estimated to ship on23 December 2024Details



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10 MG
£214.00

About This Item

Empirical Formula (Hill Notation):
C21H22N4O2
CAS Number:
Molecular Weight:
362.42
UNSPSC Code:
12352200
NACRES:
NA.77

£214.00


Availability

Estimated to ship on23 December 2024Details


Quality Level

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

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This Item
SML1147681668361554
IQ-1 A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation.

412400

IQ-1

IQ-1 ≥95% (HPLC)

SML1147

IQ-1

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 50 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

ethanol: 20 mg/mL, DMSO: 50 mg/mL

solubility

methanol: 2 mg/mL, DMSO: 200 mg/mL

General description

A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished β-catenin/p300 interaction and a concomitant increase in β-catenin/CBP usage. Co-adminitration of IQ-1 (4 µg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Miyabayashi, T., et al. 2007. Proc. Natl. Acad. Sci. USA104, 5668.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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