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Key Documents

356R-1

Sigma-Aldrich

Cytokeratin 5 & 6 (EP24 & EP67) Rabbit Monoclonal Primary Antibody

Synonym(s):

CK 5/6, cytokeratin 5/6

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP24 & EP67, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (356R-14)
vial of 0.1 mL concentrate Research Use Only (356R-14-RUO)
vial of 0.5 mL concentrate (356R-15)
vial of 1.0 mL concentrate (356R-16)
vial of 1.0 mL concentrate Research Use Only (356R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (356R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (356R-17)
vial of 7.0 mL pre-dilute ready-to-use (356R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (356R-18-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

control

mesothelioma, prostate, squamous cell carcinoma ((lung))

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KRT5(3852)

Related Categories

General description

Twenty identified cytokeratins make up a complex family of intermediate filaments.1 Cytokeratin 5 (58kDa) & cytokeratin 6 (56kDa) are type II high molecular weight keratins that are expressed in a broad range of normal tissues including breast, prostate, mesothelium, skin and esophagus.1-3 Anti-Cytokeratin 5 & 6 is a useful immunohistochemical marker in the identification of mesothelioma and lung squamous cell carcinoma.1

Quality

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Linkage

Cytokeratin 5 & 6 Positive Control Slides, Product No. 356S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris buffer, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Role of immunohistochemistry in distinguishing epithelial peritoneal mesotheliomas from peritoneal and ovarian serous carcinomas.
Ordo?ez, N.G.
Modern Pathology, 15, 6-10 (2002)
R Lersch et al.
Molecular and cellular biology, 9(9), 3685-3697 (1989-09-01)
The mitotically active basal layers of most stratified squamous epithelia express 10 to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin K5 (58 kilodaltons) and its corresponding partner
K Takahashi et al.
The Journal of biological chemistry, 270(31), 18581-18592 (1995-08-04)
The human type II keratin 6 (K6; 56 kDa) is expressed in a heterogeneous array of epithelial tissues under normal conditions, but is better known for its strong induction in stratified epithelia that feature an enhanced cell proliferation rate or
N G Ordóñez
The American journal of surgical pathology, 22(10), 1215-1221 (1998-10-20)
The immunohistochemical diagnosis of mesothelioma is commonly made by using a battery of antibodies that reacts with lung adenocarcinomas but not with epithelial mesotheliomas. Only recently have markers that are often expressed in mesotheliomas but not in adenocarcinomas been recognized.

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Antibodies as Raw Material

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