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Key Documents

PZ0213

Sigma-Aldrich

PF-04418948

≥98% (HPLC)

Synonym(s):

1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C23H20FNO5
CAS Number:
1078166-57-0
Molecular Weight:
409.41
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

InChI

1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)

InChI key

LWJGMYMNSNVCEM-UHFFFAOYSA-N

Application

PF-04418948 has been used in TG (trigeminal ganglion) explant culture.

Biochem/physiol Actions

PF-04418948 is a PGE2 Receptor (EP2) specific antagonist (IC50 = 16 nM) with greater than 2000-fold selectivity over other EP subtypes. PF-04418948 inhibits EP2 activity in smooth muscle preps from human, dog and mouse.
PF-04418948 represses the formation of colorectal tumor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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