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S9692

Sigma-Aldrich

SU 6656

≥98% (HPLC)

Synonym(s):

2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide

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About This Item

Empirical Formula (Hill Notation):
C19H21N3O3S
CAS Number:
330161-87-0
Molecular Weight:
371.45
MDL number:
MFCD10565928
UNSPSC Code:
12352200
PubChem Substance ID:
24278818
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light
under inert gas

color

orange-brown

solubility

DMSO: 12 mg/mL (orange solution)

storage temp.

−20°C

SMILES string

CN(C)S(=O)(=O)c1ccc2NC(=O)C(=C/c3cc4CCCCc4[nH]3)\c2c1

InChI

1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10-

InChI key

LOGJQOUIVKBFGH-YBEGLDIGSA-N

Gene Information

human ... SRC(6714)

Biochem/physiol Actions

SU 6656 is a selective Src family kinase inhibitor. SU 6656 inhibits Src kinase in CD34 positively-selected umbilical cord blood cells.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dioneia Araldi et al.
Pain, 158(7), 1204-1216 (2017-03-18)
We previously developed a model of opioid-induced neuroplasticity in the peripheral terminal of the nociceptor that could contribute to opioid-induced hyperalgesia, type II hyperalgesic priming. Repeated administration of mu-opioid receptor (MOR) agonists, such as DAMGO, at the peripheral terminal of
Roman Ginnan et al.
American journal of physiology. Cell physiology, 288(6), C1193-C1201 (2005-01-29)
Platelet-derived growth factor (PDGF) is an important regulator of vascular smooth muscle (VSM) cell growth and migration and has been identified as a key mediator of neointima formation resulting from vascular injury. PDGF exerts its effects, in part, through activation
Evan L Nichols et al.
Cell reports, 30(1), 9-17 (2020-01-09)
Regeneration following spinal root avulsion is broadly unsuccessful despite the regenerative capacity of other PNS-located nerves. By combining focal laser lesioning to model root avulsion in zebrafish, time-lapse imaging, and transgenesis, we identify that regenerating DRG neurons fail to recapitulate
Cecilia S Leung et al.
Nature communications, 5, 5092-5092 (2014-10-04)
Ovarian cancer is the most lethal gynaecologic malignancy in the United States, and advanced serous ovarian adenocarcinoma is responsible for most ovarian cancer deaths. However, the stroma-derived molecular determinants that modulate patient survival are yet to be characterized. Here we
H C Chua et al.
Science advances, 6(17), eaaz3154-eaaz3154 (2020-06-05)
The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations are life-threatening in humans and knockout is lethal in mice. However, the basic functional and pharmacological properties of NALCN have remained elusive. Here, we found that robust
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