R6520
Rolipram
≥98% (HPLC), solid, cAMP-specific phosphodiesterase (PDE4) inhibitor
Synonym(s):
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK 62711
About This Item
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product name
Rolipram, solid, ≥98% (HPLC)
biological source
synthetic (organic)
Quality Level
Assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
H2O: 0.2 mg/mL
ethanol: 7 mg/mL
DMSO: 7.3 mg/mL
SMILES string
COc1ccc(cc1OC2CCCC2)C3CNC(=O)C3
InChI
1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
InChI key
HJORMJIFDVBMOB-UHFFFAOYSA-N
Gene Information
human ... LITAF(9516) , PDE3A(5139) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE5A(8654) , PDE7A(5150)
mouse ... Pde4a(18577)
rat ... Adora1(29290) , Pde1b(29691) , Pde2a(81743) , Pde3a(50678) , Pde4a(25638) , Pde4b(24626) , Pde4c(290646) , Pde5a(171115)
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General description
Application
- to investigate its effects on testicular torsion–detorsion injury(36)
- to block the effects of phosphodiesterase-4 (PDE4)(37)
- as a component in chemically induced long-term potentiation (cLTP) induction media(38)
Biochem/physiol Actions
Features and Benefits
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Articles
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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