401098
Human IgA, Plasma
Synonym(s):
IgA serum, Plasma IgA
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.77
Recommended Products
Assay
≥95% (SDS-PAGE)
Quality Level
form
liquid
contains
≤0.1% sodium azide as preservative
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
isotype
IgA
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Immunoglobulin A (IgA) is the most dominantly generated antibody isotype. They are majorly secreted in the intestinal mucosa. IgA is present in colostrum, serum, saliva, and nasal fluid. It exists in two isotypic forms namely: IgA1 and IgA2. It is generated as secretory IgA (sIgA) and serum IgA. Serum IgA is present in the dimeric form linked by disulfide bond with an additional J chain. sIgA occurs in a monomeric form with two heavy and two light chains.
Application
Human IgA, Plasma has been used in enzyme-linked immunosorbent assay (ELISA).
Biochem/physiol Actions
Immunoglobulin A (IgA) initiates the alternative pathway of the complement system to elicit protective functions. It facilitates antibody-dependent cell-mediated cytotoxicity (ADCC) by attaching to leukocytes. This interaction boosts microbial destruction. IgA performances the first line of defense in antigen clearance. It avoids proteolysis and hinders the uptake of viral, bacterial, or antigen attachment. It lowers inflammation aroused by the classical pathway complement activation.
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Physical form
In 100 mM NaCl, 100 mM Tris-HCl, pH 8.0.
Preparation Note
Prepared from plasma that has been shown by certified tests to be nonreactive for HBsAg and for antibodies to HCV, HBc, HIV-1 and HIV-2.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Variables associated with assay conditions will dictate the proper working dilution.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Handbook of Human Immunology (2008)
International Journal of Immunogenetics null
Andrew J Macpherson et al.
Annual review of immunology, 36, 359-381 (2018-02-06)
IgA is the dominant immunoglobulin isotype produced in mammals, largely secreted across the intestinal mucosal surface. Although induction of IgA has been a hallmark feature of microbiota colonization following colonization in germ-free animals, until recently appreciation of the function of
The structure and function of human IgA.
M A Kerr
The Biochemical journal, 271(2), 285-296 (1990-10-15)
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