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biological source
human
Quality Level
100
300
Assay
>98% (SDS-PAGE)
form
liquid
manufacturer/tradename
Chemicon®
concentration
3.5 mg/mL
NCBI accession no.
UniProt accession no.
General description
C-reactive protein (CRP) is a homopentameric acute-phase inflammatory protein, which belongs to the pentraxin family. It is a highly conserved plasma protein produced mainly in liver hepatocytes. It is also synthesized by lymphocytes, smooth muscle cells, macrophages, endothelial cells, and adipocytes.
Application
C-reactive protein (CRP) has been used:
- as a model analyte for interference-reduced detection of CRP in serum using non-competitive sandwich immunoassay in combination with surface plasmon field-enhanced fluorescence spectroscopy (SPFS)
- to determine the involvement of collectin placenta 1 (CL-P1) in CRP-mediated complement activation and to investigate the downstream effects of this complement activation
- to examine to study the effects of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) on CRP-induced complement activation by interacting with CRP to develop an inflammatory pathogenic response
Biochem/physiol Actions
C-reactive protein (CRP) plays a vital role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release. It also regulates the production of interleukin-6 and tumor necrosis factor-α. Patients suffering from appendicitis, cholecystitis, pancreatitis, and meningitis have elevated levels of CRP. CRP facilitates the uptake of low-density lipoprotein in macrophages. It has a crucial role in the pathophysiology of cardiovascular disease, which makes it a useful marker for inflammation and cardiovascular events.
Quality
No precipitin bands when tested at 2 mg/mL against anti-whole human serum.
Physical form
Liquid in 100mM NaCl, 10mM Tris-HCl with 0.1% sodium azide, 2mM CaCl2
Storage and Stability
Maintain under sterile conditions at 2-8°C for up to one year. Do not freeze. Full safety precautions should be taken as in the handling of any potentially infective body fluid.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
AG723-K:
AG723-KC:
AG723:
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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