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A4941

Sigma-Aldrich

Activin A human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

Synonym(s):

Activin A Protein, Growth Factor, Human Growth Factor

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About This Item

EC Number:
201-069-1
MDL number:
MFCD02685750
UNSPSC Code:
12352202
NACRES:
NA.32

Product Name

Activin A human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

200

recombinant

expressed in baculovirus infected insect cells

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

1-10 ng/mL ED50

mol wt

dimer 26 kDa (containing 116 amino acid residues βA subunits)

packaging

pkg of 10 μg
pkg of 5 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P08476

storage temp.

−20°C

Gene Information

human ... INHBA(3624)

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General description

Activin A gene with two exons is mapped to human chromosome 2q35. Activin A also known as inhibin α-subunit belongs to the TGF-β (transforming growth factor-β) superfamily of proteins and its expression is exclusive to gonads, placenta and adrenal cortex.

Application

Activin A human has been used as a constituent of modified barth′s saline used in in vitro induction of pronephros. It has also been used as a constituent of Roswell Park memorial institute (RPMI) media to induce pancreatic differentiation of multipotent dermal fibroblasts in vitro.

Biochem/physiol Actions

Activins play a vital role in the regulation of hormonogenesis, cellular homeostasis and differentiation programs. Elevated expression of activin A and B leads to the loss of muscle mass. Both activin A and B have a potential to act as a serum markers of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Physical form

Lyophilized from 0.2 μm filtered solution in 10 mM sodium citrate, pH 3.0.

Analysis Note

The biological activity is determined by its ability to inhibit the proliferation of mouse MPC-11 cells.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Cartagena Act

Cartagena Act Listed

JAN Code

A4941-10UG:
A4941-VAR:
A4941-BULK:
A4941-5UG-PW:
A4941-10UG-PW:
A4941-5UG:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT8336
MKCR1794
MKCS3877
MKCS7167
MKCR6164

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Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters
Bi D, et al.
BMC Cell Biology, 11, 1-7 (2010)
Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study
Lidbury BA, et al.
Journal of Translational Medicine, 15 (2017)
Inhibin Alpha-Subunit (INHA) Expression in Adrenocortical Cancer Is Linked to Genetic and Epigenetic INHA Promoter Variation
Hofland J, et al.
PLoS ONE, 9, e104944-e104944 (2014)
T K Woodruff
Biochemical pharmacology, 55(7), 953-963 (1998-05-30)
Activin is an important molecule that regulates hormonogenesis, cellular homeostasis (divide or die pathways), and differentiation programs (developmentally and in adult cells). The cellular mechanisms that integrate an activin signal into a physiological response include a binary receptor complex and
Valérie Bello et al.
Developmental biology, 317(1), 106-120 (2008-04-02)
Dystroglycan (Dg) is a laminin receptor that is expressed at the interface between the basement membrane and the cell membrane. Dg has been reported to play a role in skeletal muscle cell stability, morphogenesis of neuroepithelial tissues, and in regulating
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