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Safety Information

H1917

Sigma-Aldrich

Histone H1 human

Synonym(s):

Histone, Human

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About This Item

CAS Number:
1523001-32-2
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human

Quality Level

200

recombinant

expressed in E. coli

form

liquid

concentration

1 mg/mL

UniProt accession no.

P07305

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... H1.0(3005)

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General description

Histone H1 is part of high-order chromatin structure and is a linker protein associated with nucleosome core particle. Histone H1 is mapped to human chromosome 6. Histone H1 exists in different isoforms. Histone H1 comprises of N-terminal hydrophobic rich region, central globular domain and a C-terminal with intrinsically disordered regions.

Biochem/physiol Actions

The C-terminal regions of histone H1 is essential for binding to chromatin. The placement of H1 is necessary for nucleosome positioning. Histone H1 maintains chromosome architecture and stabilises compaction of nucleosomes during interphase. H1-null mutants display increased rate of chromatin aberration and growth defects. Histone H1 modulates embryogenesis and DNA repair. The H1 histone undergoes posttranslational modification including phosphorylation, methylation and acetylation, each of which carry out different physiological functions. Histone H1 and its variants contribute to the pathogenesis in cancer, Alzheimer′s disease, male infertility and immunity related disorders.

Physical form

Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

H1917-100UG:
H1917-VAR:
H1917-BULK:
H1917-100UG-PW:

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Certificates of Analysis (COA)

Lot/Batch Number
0000262831
0000275916
0000270403
0000252258
0000284219

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Linker Histone in Diseases
Ye X, et al.
International Journal of Biological Sciences, 13(8), 1008-1018 (2017)
The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle
Hergeth SP and Schneider R
EMBO Reports, 16(11), 1439-1453 (2015)
H1 histones: current perspectives and challenges
Harshman SW, et al.
Nucleic Acids Research, 41(21), 9593-9609 (2013)
Dynamic placement of the linker histone H1 associated with nucleosome arrangement and gene transcription in early Drosophila embryonic development
Hu J, et al.
Cell Death & Disease, 9(7), 765-765 (2018)
Histone H1 null vertebrate cells exhibit altered nucleosome architecture
Hashimoto H, et al.
Nucleic Acids Research, 38(11), 3533-3545 (2010)
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