Q0632

Quinapril hydrochloride

≥98% (HPLC), solid

• Synonym(s): (3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride
• Empirical Formula (Hill Notation): C₂₅H₃₀N₂O₅ · HCl
• CAS Number: 82586-55-8
• Molecular Weight: 474.98
• MDL number: MFCD00889215
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823858
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: H₂O: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2Cc3ccccc3C[C@H]2C(O)=O
• InChI: 1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1
• InChI key: IBBLRJGOOANPTQ-JKVLGAQCSA-N
• Gene Information: human ... ACE(1636)

Description

Application

Quinapril hydrochloride has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on renal tubular epithelial cell proliferation in human renal tubular epithelial cells. It has also been used as an ACE inhibitor to evaluate its effects on the expression of angiotensin II (AII) in patient-derived Atheroma samples.

Biochem/physiol Actions

Quinapril has been studied to exhibit therapeutic effects against hypertension and congestive heart failure.

Quinapril is a short-acting angiotensin converting enzyme (ACE) inhibitor.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H361d,H372
• Precautionary Statements: P202 - P260 - P264 - P280 - P308 + P313 - P405
• Hazard Classifications: Repr. 2 - STOT RE 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves