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SML1109

Sigma-Aldrich

KU-55933

≥98% (HPLC)

Synonym(s):

2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-Pyran-4-one, 2-(Morpholin-4-yl)-6-(thianthren-1-yl)-4H-pyran-4-one

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100 μL
₩693,042

₩693,042


Estimated to ship onFebruary 20, 2025Details


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100 μL
₩693,042

About This Item

Empirical Formula (Hill Notation):
C21H17NO3S2
CAS Number:
Molecular Weight:
395.49
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

₩693,042


Estimated to ship onFebruary 20, 2025Details


Request a Bulk Order

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5

InChI

1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2

InChI key

XRKYMMUGXMWDAO-UHFFFAOYSA-N

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1 of 4

This Item
R128HPA056416AB9080
biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

species reactivity

human, mouse, rat

species reactivity

canine, rabbit, rat, chicken, amphibian, guinea pig, mouse, fish, human

species reactivity

human

species reactivity

mouse, human, rat

technique(s)

immunocytochemistry: suitable, western blot: suitable, immunohistochemistry: suitable

technique(s)

immunohistochemistry (frozen sections): 1 μg/mL using 4% paraformaldehyde-fixed, frozen mouse brain tissue, immunoprecipitation (IP): suitable, western blot (chemiluminescent): 1 μg/mL

technique(s)

immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:50-1:200

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable

Application

KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.[1][2]

Biochem/physiol Actions

KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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