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  • Adaptation of dynamic covalent systems of imine constituents to medium change by component redistribution under reversible phase separation.

Adaptation of dynamic covalent systems of imine constituents to medium change by component redistribution under reversible phase separation.

Journal of the American Chemical Society (2012-07-13)
Nema Hafezi, Jean-Marie Lehn
ABSTRACT

A dynamic covalent library of interconverting imine constituents, dissolved in an acetonitrile/water mixture, undergoes constitutional reorganization upon phase separation induced by a physical stimulus (heat) or a chemical effector (inorganic salt, carbohydrate, organic solvent). The process has been made reversible, regenerating the initial library upon phase reunification. It represents the behavior of a dynamic covalent library upon reversible phase separation and its adaptation to a phase change, with up-regulation in each phase of the fittest constituents by component selection. Finally, the system exemplifies the splitting of a 2D (square) constitutional dynamic network into a 3D (cube) one.

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