06-520

Anti-Na+/K+ ATPase α-1 Antibody

Upstate^®, from rabbit

• 동의어(들): Anti-CMT2DD
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: purified antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 종 반응성: bovine, rat, human
• 포장: antibody small pack of 25 μg
• 제조업체/상표: Upstate^®
• 기술: immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• 동형: IgG
• NCBI 수납 번호: NM_001001586
• UniProt 수납 번호: P05023
• 배송 상태: ambient
• 타겟 번역 후 변형: unmodified
• 유전자 정보: rat ... Atp1A1(24211)

설명

일반 설명

Na+/K+ ATPase α-1 is a human gene and functions to maintain Na+ and K+ across the cell membrane which is important for osmoregulation. It is a component of (Na+/K+) ATPase, a transporter that catalyzes the hydrolysis of ATP and transports sodium and potassium ions across the plasma membrane. It also partners with Src and other signaling proteins. Binding of ouabain and other cardiotonic steroids to the (Na+/K+) ATPase activates Src, resulting in the assembly and activation of multiple signaling cascades. Binding of ouabain also induces a positive inotropic effect. Diseases associated with ATPase are Thyrotoxic periodic paralysis and hyperthyroidism. (References: Wikipedia and http://www.bioportfolio.com/gene/476-ATP1A1.html)

특이성

Expected to cross-react with Rat-100%, Mouse-99%; human, pig, rabbit, monkey-96%.

Recognizes the α-1 subunit isoform of Na⁺/K⁺ ATPase.

면역원

Epitope: Cytoplasmic domain

GST-tagged ATPase.

애플리케이션

Research Category
Neuroscience

Research Sub Category
Ion Channels & Transporters

This Anti-Na+/K+ ATPase α-1 Antibody is validated for use in IC, IP, WB for the detection of Na+/K+ ATPase α-1.

품질

Routinely evaluated by Immunoprecipitation on rat brain microsomal prep. lysate.

표적 설명

112 kDa

물리적 형태

Format: Purified

Protein A purified

Purified antibody in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl and 0.05% NaN3.

저장 및 안정성

Stable for 1 year at 2-8ºC from date of receipt.

분석 메모

Control
Rat Brain Microsomal Prep. lysate.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.