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Merck
모든 사진(1)

문서

196871

Sigma-Aldrich

BAY 11-7082

InSolution, ≥95%, Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α

동의어(들):

InSolution BAY 11-7082

로그인조직 및 계약 가격 보기
모든 사진(1)

About This Item

실험식(Hill 표기법):
C10H9NO2S
Molecular Weight:
207.25
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥95% (HPLC)

형태

liquid

효능

10 μM IC50

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
desiccated (hygroscopic)
protect from light

배송 상태

wet ice

저장 온도

2-8°C

일반 설명

Potential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC50 = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50 ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.

생화학적/생리학적 작용

Cell permeable: yes
Primary Target
TNF-α-inducible phosphorylation of IκBα
Product does not compete with ATP.
Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

물리적 형태

Supplied as a 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196870) in DMSO.

기타 정보

Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
Izban, K.F., et al. 2000. Hum. Pathol.31, 1482.
Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Flash Point (°C)

87 °C - closed cup - (Dimethylsulfoxide)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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