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R8781

Sigma-Aldrich

Rapamycin

Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

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Synonym(s):
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution
Empirical Formula (Hill Notation):
C51H79NO13
Molecular Weight:
914.17
EC Number:
NACRES:
NA.77

biological source

Streptomyces hygroscopicus

Quality Level

vapor pressure

0.56 hPa ( 20 °C)

assay

≥95% (HPLC)

form

solution

autoignition temp.

301 °C

concentration

2.5 mg/mL in DMSO (2.74 mM)

color

colorless to yellow

antibiotic activity spectrum

fungi
yeast

mode of action

enzyme | inhibits

storage temp.

−20°C

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R0395401251SML1295
vibrant-m

R8781

Rapamycin

vibrant-m

401251

IM-412

vibrant-m

SML1295

RBC8

form

solution

form

powder

form

solid

form

powder

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥98% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

color

colorless to yellow

color

off-white

color

off-white

color

white to beige

biological source

Streptomyces hygroscopicus

biological source

-

biological source

-

biological source

-

General description

Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.

Packaging

200uL

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Is Hygroscopic.
Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Rapamycin probe summary on the Chemical Probes Portal website.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Sigma-Aldrich

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