444250

MMP Inhibitor I

The MMP Inhibitor I controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 동의어(들): MMP Inhibitor I, FN-439
• 실험식(Hill 표기법): C₂₃H₃₄N₆O₆
• Molecular Weight: 490.55
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 효능: 1 μM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: water: 1 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A tetrapeptidyl hydroxamic acid that inhibits MMP-1 and MMP-8 (IC₅₀ = 1.0 µM), MMP-9 (IC₅₀ = 30 µM) and MMP-3 (IC₅₀ = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. Nos. 53702 or 537088) or human granulocyte elastase.

A tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC₅₀ = 1 µM), granulocyte gelatinase (MMP-9; IC₅₀ = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC₅₀ = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. No. 53702) or human neutrophil elastase.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
MMP-1, MMP-8

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Standard Handling (A)

서열

4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]

재구성

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

기타 정보

Hagemamn, T., et al. 2004. Carcinogenesis25, 1543.
Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable