553211

Rapamycin

≥95% (HPLC), solution, mTOR inhibitor, Calbiochem

• 동의어(들): InSolution Rapamycin, mTOR Inhibitor I
• 실험식(Hill 표기법): C₅₁H₇₉NO₁₃
• Molecular Weight: 914.17
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solution
• 제조업체/상표: Calbiochem^®
• 저장 조건: desiccated (hygroscopic); protect from light
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

일반 설명

Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC₅₀ = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G₁ phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G₁ phase.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Mammalian target of rapamycin (mTOR)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

물리적 형태

2.5 mg/mL solution in DMSO (2.74 mM)

재구성

Following initial use, aliquot and freeze (-20°C).

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Flash Point (°C): 87 °C - closed cup - (Dimethylsulfoxide)