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Merck
모든 사진(1)

주요 문서

MAB1617

Sigma-Aldrich

Anti-Kinesin Antibody, light chain, clone L2

clone L2, Chemicon®, from mouse

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
클론:
L2, monoclonal
application:
ELISA
IP
RIA
WB
기술:
ELISA: suitable
immunoprecipitation (IP): suitable
radioimmunoassay: suitable
western blot: suitable
citations:
6

생물학적 소스

mouse

Quality Level

항체 형태

purified antibody

항체 생산 유형

primary antibodies

클론

L2, monoclonal

종 반응성(상동성에 의해 예측)

mammals

제조업체/상표

Chemicon®

기술

ELISA: suitable
immunoprecipitation (IP): suitable
radioimmunoassay: suitable
western blot: suitable

동형

IgG2a

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... KLC1(3831)

특이성

Reacts with the light chain of kinesin near the C-terminal.

면역원

Bovine brain kinesin.
Epitope: light chain

애플리케이션

Anti-Kinesin Antibody, light chain, clone L2 is an antibody against Kinesin for use in ELISA, IP, RIA & WB.
Immunoblotting

Immunoprecipitation

EIA/RIA

Optimal working dilutions must be determined by the end user.

Note: Does not work for immunohistochemistry and works only marginally for immunocytochemistry.
Research Category
Cell Structure
Research Sub Category
Cytoskeleton

물리적 형태

Format: Purified
Liquid in 0.02 M Phosphate buffer, 0.25 M NaCl with 0.1% sodium azide.

저장 및 안정성

Maintain at 2-8°C in undiluted aliquots for up to 6 months.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Kyoko Okada et al.
Nature communications, 14(1), 5833-5833 (2023-09-21)
Processive transport by the microtubule motor cytoplasmic dynein requires the regulated assembly of a dynein-dynactin-adapter complex. Interactions between dynein and dynactin were initially ascribed to the dynein intermediate chain N-terminus and the dynactin subunit p150Glued. However, recent cryo-EM structures have
Yanpeng Zheng et al.
FEBS letters, 590(7), 1028-1037 (2016-03-19)
Although the exact etiology and pathogenesis of Alzheimer's disease (AD) are still unclear, amyloid-β (Aβ) generated by the proteolytic processing of amyloid-β precursor protein (APP) aggregate to form toxic amyloid species. Kinesin-1 is the first identified ATP-dependent axonal transport motor
Hao Wu et al.
The Journal of biological chemistry, 295(19), 6605-6628 (2020-03-01)
Motor protein-based active transport is essential for mRNA localization and local translation in animal cells, yet how mRNA granules interact with motor proteins remains poorly understood. Using an unbiased yeast two-hybrid screen for interactions between murine RNA-binding proteins (RBPs) and
Ping Shi et al.
Biochimica et biophysica acta, 1802(9), 707-716 (2010-06-01)
Transport of material and signals between extensive neuronal processes and the cell body is essential to neuronal physiology and survival. Slowing of axonal transport has been shown to occur before the onset of symptoms in amyotrophic lateral sclerosis (ALS). We
Anuttama Kulkarni et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(3), 965-974 (2016-12-07)
Acetylcholinesterase (AChE), which is implicated in the pathophysiology of neurological disorders, is distributed along the axon and enriched at the presynaptic basal lamina. It hydrolyses the neurotransmitter acetylcholine, which inhibits synaptic transmission. Aberrant AChE activity and ectopic axonal accumulation of

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