추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified antibody
항체 생산 유형
primary antibodies
클론
DD/A11, monoclonal
mAbA11, monoclonal
종 반응성
human, bovine, mouse
종 반응성(상동성에 의해 예측)
rat
제조업체/상표
Chemicon®
기술
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
동형
IgG2a
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
glycosylation
유전자 정보
human ... AGER(177)
일반 설명
RAGE (Receptor for Advanced Glycosylation End Products) is a 35 kDa cell surface receptor that binds molecules modified by advanced glycation end products (AGEs), an irreversible non-enzymatic reaction occuring from the interaction of proteins and lipids with glucose. The increased expression of RAGE is associated with many disorders, such as diabetic vasculopathy, neuropathy, retinopathy and neuropathy, Alzheimer’s disease and immune/inflammatory reactions of the vessel walls. AGE/RAGE accumulates at sites of vascular disease in diabetes, but blockade of RAGE suppresses development of atherosclerosis and vascular disorders. RAGE binds to amyloid beta, which is overproduced in neurons and vessels in Alzheimer′s disease, and this interaction results in oxidative stress leading to neuronal degeneration.
특이성
RAGE (Receptor for Advanced Glycosylated End Products). The antibody recognizes both natural and recombinant RAGE.
면역원
Recombinant truncated extracellular part of RAGE produced in E. coli.
애플리케이션
Anti-RAGE Antibody, clone DD/A11 or A11 is an antibody against RAGE for use in ELISA, IC, IH & WB.
Immunohistochemistry:
A previous lot of this antibody was shown to be reactive on paraffin embedded tissue sections.
Immunocytochemistry:
A previous lot was shown to work on cells fixed with ice cold acetone using a Cy3 conjugated secondary antibody.
ELISA:
A previous lot was shown to work on direct ELISA.
Immunoblotting:
Recognizes a band of ~48kDa in bovine lung extract.
Optimal working dilutions must be determined by end user.
A previous lot of this antibody was shown to be reactive on paraffin embedded tissue sections.
Immunocytochemistry:
A previous lot was shown to work on cells fixed with ice cold acetone using a Cy3 conjugated secondary antibody.
ELISA:
A previous lot was shown to work on direct ELISA.
Immunoblotting:
Recognizes a band of ~48kDa in bovine lung extract.
Optimal working dilutions must be determined by end user.
품질
Routinely evaluated by Western Blot on Mouse Brain lysates.
Western Blot:
1:500 dilution of this lot detected RAGE on 10 μg of Mouse Brain lysates.
Western Blot:
1:500 dilution of this lot detected RAGE on 10 μg of Mouse Brain lysates.
표적 설명
48 kDa
물리적 형태
Format: Purified
Purified mouse monoclonal IgG2a in buffer containing 0.02 M phosphate buffer, 0.25 M NaCl, and 0.1% sodium azide.
분석 메모
Control
Lung tissue, mouse brain lysate.
Lung tissue, mouse brain lysate.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Atsushi Fujiya et al.
Obesity (Silver Spring, Md.), 22(2), 371-379 (2013-06-28)
The S100 calcium binding protein B (S100B) implicated in brain inflammation acts via the receptor of advanced glycation end products (RAGE) and is also secreted from adipocytes. We investigated the role of S100B in the interaction between adipocytes and macrophages
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis.
Loeser, RF; Yammani, RR; Carlson, CS; Chen, H; Cole, A; Im, HJ; Bursch, LS; Yan, SD
Arthritis and Rheumatism null
Anna Kamynina et al.
Journal of cellular physiology, 236(9), 6496-6506 (2021-02-12)
The receptor for advanced glycation end products (RAGE) is a signal receptor first shown to be activated by advanced glycation end products, but also by a variety of signal molecules, including pathological advanced oxidation protein products and β-amyloid. However, most
Patrick Most et al.
The Journal of biological chemistry, 278(48), 48404-48412 (2003-09-10)
S100A1 is a Ca2+-binding protein of the EF-hand type that belongs to the S100 protein family. It is specifically expressed in the myocardium at high levels and is considered to be an important regulator of cardiac contractility. Because the S100A1
Mei-Chih Chen et al.
Cell death & disease, 11(4), 265-265 (2020-04-25)
RAGE (receptor for advanced glycation end-product) is thought to be associated with metastasis and poor prognosis of various types of cancer. However, RAGE is constitutively expressed in the normal lung and down-regulated in cancerous lung, while the opposite evidence shows
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