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I1645

Sigma-Aldrich

Interleukin-8 human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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Synonym(s):
IL-8
MDL number:
NACRES:
NA.32

biological source

human

Quality Level

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

mol wt

8.4 kDa

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... IL8(3576)

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Interleukin-8 human

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Interleukin-13 human

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Interleukin-2 human

recombinant

expressed in E. coli

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in E. coli

recombinant

expressed in Pichia pastoris

biological source

human

biological source

human

biological source

human

biological source

human

assay

≥98% (SDS-PAGE and HPLC)

assay

≥97% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

≥98% (SDS-PAGE and HPLC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

packaging

pkg of 10 μg

packaging

pkg of 5 μg

packaging

pkg of 10 μg

packaging

pkg of 10KU

Application

Interleukin-8 (IL-8) human has ben used to:
  • measure neutrophil chemotoxis
  • study the uptake of apoptotic cells by meningothelial cells
  • study the effect of IL-8 on expression and secretion of urocortin-1 by human umbilical vein endothelial cells

Biochem/physiol Actions

Interleukin-8 (IL-8) was formerly called monocyte-derived neutrophil chemotactic factor. It belongs to the chemokine α or C-X-C family. Like other members of this family, the mature form of IL-8 has four cysteine residues and the first two cysteine residues are separated by glutamine. IL-8 shows chemotactic activity in vitro for T cells, neutrophils and basophils. Mutation in IL-8 can increase risk to acute pancreatitis.
Interleukin-8 (IL-8), formerly called monocyte-derived neutrophil chemotactic factor, belongs to the chemokine α or C-X-C family. The mature form of IL-8 has 4 cysteine residues, as do the other members of the chemokine family and the first two cysteine residues are separated by glutamine. Mature human IL-8 consists of 72 amino acids with a molecular mass of 8.4 kDa. IL-8 exhibits chemotactic activity in vitro for T cells, basophils, as measured by enzymes including myeloperoxidase, α-mannosidase and β-glucuronidase. IL-8 is an angiogenic factor.

Physical form

Lyophilized from a 0.2 μm filtered solution with no additives.

Analysis Note

The biological activity is determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/ml.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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