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I2778

Sigma-Aldrich

Interleukin-1α human

IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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Synonym(s):
IL-1α, hIL-1α., Interleukin-1α human, Lymphocyte activating factor
MDL number:
NACRES:
NA.77

biological source

human

Quality Level

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

quality

endotoxin tested

mol wt

~17 kDa

packaging

pkg of 2 and 10 μg

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... IL1A(3552)

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Interleukin-1α human

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recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

-

assay

≥97% (SDS-PAGE)

biological source

human

biological source

human

biological source

human

biological source

mouse

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

100

packaging

pkg of 2 and 10 μg

packaging

pkg of 10 μg

packaging

pkg of 5X10 μg, pkg of 10 μg

packaging

pkg of 5 and 25 μg

General description

Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family. It is located intracellularly in hematopoietic and non-hematopoietic cells. IL-1α gene is located on the human chromosome at 2q14.1.

Application

Interleukin-1α (IL-1α) has been used:
  • to study its effects on human colorectal adenocarcinoma cells
  • to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells
  • to pre-stimulate human THP-1 monocytes

Biochem/physiol Actions

Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin.

Physical form

Lyophilized from 0.2 μm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 μg bovine serum albumin (BSA) per μg cytokine.

Analysis Note

The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Articles

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

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