D5919
Diacylglycerol Kinase Inhibitor I
solid
동의어(들):
6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]-pyrimidin-5-one, R59022
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C27H26FN3OS
CAS Number:
Molecular Weight:
459.58
MDL number:
UNSPSC 코드:
41106300
PubChem Substance ID:
NACRES:
NA.77
추천 제품
생물학적 소스
synthetic (organic)
Quality Level
분석
≥98% (HPLC)
양식
solid
색상
pale yellow
solubility
0.1 M HCl: slightly soluble
0.1 M NaOH: slightly soluble
DMSO: soluble
H2O: insoluble
ethanol: soluble
ethyl acetate: soluble
저장 온도
−20°C
SMILES string
CC1=C(CCN2CCC(\CC2)=C(\c3ccccc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1
InChI
1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
InChI key
MFVJXLPANKSLLD-UHFFFAOYSA-N
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일반 설명
Diacylglycerol Kinase Inhibitor I prevents the formation of foreign body giant cell (FBGC). It inhibits the phosphorylation of diacylglycerol to phosphatidic acid. Diacylglycerol Kinase Inhibitor I functions as a serotonin (5-HT) receptor (5-HTR) antagonist. It stimulates apoptosis and autophagy in neuronal cell line NG108-15.
애플리케이션
Diacylglycerol Kinase Inhibitor I has been used as an inhibitor to study suppression of T cell function using advanced generation human CAR (chimeric antigen receptors) T cells.
생화학적/생리학적 작용
Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoxyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors
Moon EK, et al.
Clinical Cancer Research, 197-201 (2014)
Eric Ruelland et al.
Plant physiology, 130(2), 999-1007 (2002-10-12)
The signaling events generated by a cold exposure are poorly known in plants. We were interested in checking the possible activation of enzymes of the phosphoinositide signaling pathway in response to a temperature drop. In Arabidopsis suspension cells labeled with
Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol kinase inhibitor R59022, staurosporine and okadaic acid
Packham MA, et al.
The Biochemical Journal, 290(3), 849-856 (1993)
Amy K McNally et al.
The American journal of pathology, 163(3), 1147-1156 (2003-08-26)
Multinucleated foreign body giant cells (FBGCs) form by monocyte-derived macrophage fusion on implanted biomedical devices and are believed to mediate oxidative damage to biomaterial surfaces. Our in vitro system of human macrophage culture and interleukin (IL)-4-induced FBGC formation was developed
Ana M Laxalt et al.
The Journal of biological chemistry, 282(29), 21160-21168 (2007-05-11)
Nitric Oxide (NO) is a second messenger related to development and (a)biotic stress responses in plants. We have studied the role of NO in signaling during plant defense responses upon xylanase elicitation. Treatment of tomato cell cultures with the fungal
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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