M1508
4-Methylumbelliferone sodium salt
fluorogenic, ≥98% (HPLC), crystalline
동의어(들):
β-Methylumbelliferone, 7-Hydroxy-4-methylcoumarin
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모든 사진(1)
About This Item
Linear Formula:
C10H7O3Na
CAS Number:
Molecular Weight:
198.15
EC Number:
MDL number:
UNSPSC 코드:
12352204
PubChem Substance ID:
NACRES:
NA.32
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추천 제품
제품명
4-Methylumbelliferone sodium salt, ≥98% (HPLC), crystalline
Quality Level
분석
≥98% (HPLC)
양식
crystalline
색상
yellow
solubility
water: 50 mg/mL
SMILES string
[Na+].CC1=CC(=O)Oc2cc([O-])ccc12
InChI
1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
InChI key
JGMQHDNPUCPRQE-UHFFFAOYSA-M
일반 설명
4-methylumbelliferone (4-MU) is a coumarin derivative.[1]
애플리케이션
4-Methylumbelliferone sodium salt has been used:
- as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liver[2]
- as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action[3]
- in cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer[4]
생화학적/생리학적 작용
4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic[5], and antitumor properties.[1] 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response.[5] 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.[2]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
Matías A Pibuel et al.
Glycobiology, 31(1), 29-43 (2020-05-31)
Glioblastoma (GBM), the most frequent primary tumor of the central nervous system, has a median survival of 14.6 months. 4-Methylumbelliferone (4MU) is a coumarin derivative widely used as a hyaluronan synthesis inhibitor with proven antitumor activity and without toxic effects reported.
Molly Stapleton et al.
Molecular genetics and metabolism reports, 22, 100563-100563 (2020-01-21)
Mucopolysaccharidoses (MPS) are a family of lysosomal storage disorders which can lead to degenerative and irreversible skeletal, cardiovascular, pulmonary, and neurological damage. Current treatments, including hematopoietic stem cell transplantation and enzyme replacement therapy, have been found most effective if administered
Rebecca M DuBois et al.
PLoS pathogens, 7(12), e1002398-e1002398 (2011-12-07)
Highly pathogenic avian influenza viruses of the H5N1 subtype continue to threaten agriculture and human health. Here, we use biochemistry and x-ray crystallography to reveal how amino-acid variations in the hemagglutinin (HA) protein contribute to the pathogenicity of H5N1 influenza
Peter Pushko et al.
Virology, 501, 176-182 (2016-12-10)
Avian influenza (AI) viruses circulating in wild birds pose a serious threat to public health. Human and veterinary vaccines against AI subtypes are needed. Here we prepared triple-subtype VLPs that co-localized H5, H7 and H9 antigens derived from H5N1, H7N3
Gale E Smith et al.
Virology, 509, 90-97 (2017-06-19)
Avian influenza A (H5N1) viruses represent a growing threat for an influenza pandemic. The presence of widespread avian influenza virus infections further emphasizes the need for vaccine strategies for control of pre-pandemic H5N1 and other avian influenza subtypes. Influenza neuraminidase
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