M2786

3-Maleimidobenzoic acid N-hydroxysuccinimide ester

crystalline

• 동의어(들): MBS
• 실험식(Hill 표기법): C₁₅H₁₀N₂O₆
• CAS Number: 58626-38-3
• Molecular Weight: 314.25
• Beilstein: 1505254
• MDL number: MFCD00005514
• UNSPSC 코드: 12352108
• PubChem Substance ID: 24896768
• NACRES: NA.22

속성

• 형태: crystalline
• Quality Level: 200
• 반응 적합성: reagent type: cross-linking reagent
• mp: 175-177 °C (lit.)
• solubility: DMSO: ≤20 mg/mL
• 작용기: NHS ester; maleimide
• 저장 온도: −20°C
• SMILES string: O=C1CCC(N1OC(C2=CC=CC(N3C(C=CC3=O)=O)=C2)=O)=O
• InChI: 1S/C15H10N2O6/c18-11-4-5-12(19)16(11)10-3-1-2-9(8-10)15(22)23-17-13(20)6-7-14(17)21/h1-5,8H,6-7H2
• InChI key: LLXVXPPXELIDGQ-UHFFFAOYSA-N

설명

일반 설명

may require addition of solvent to coupling buffer to at least 5% to maintain solubility

애플리케이션

3-Maleimidobenzoic acid N-hydroxysuccinimide ester (MBS) has been used as a protein cross-linker. It has been used for the stabilization of actin filaments in plant tissue samples.

3-Maleimidobenzoic acid N-hydroxysuccinimide ester has been used:

• in the fixation of pollen in Arabidopis
• as a component of Murashige and Skoog (MS) medium to stabilize F-actin in Eucalyptus root hairs
• in the fixation of F-actin labelled pollen tubes of Lilium davidii

Heterobifunctional crosslinking reagent reactive toward primary amine and sulfhydryl. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.0, followed by coupling to compounds containing sulfhydryl by thioether at same pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.

생화학적/생리학적 작용

3-Maleimidobenzoic acid N-hydroxysuccinimide is used as a fixative for the preservation of pollen tube F-actin distribution. It imposes less damage when used on pollen tubes.

기타 정보

The aryl maleimide is less stable than alkyl maleimide linkers.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable