MAK112

Arginase Activity Assay Kit

sufficient for 200 colorimetric tests

• 동의어(들): Arginase Test Kit
• UNSPSC 코드: 12161503
• NACRES: NA.84

속성

• 사용: sufficient for 200 colorimetric tests
• 검출 방법: colorimetric
• 관련 질환(들): cancer; immunological diseases; gastrointestinal diseases
• 저장 온도: −20°C
• 유전자 정보: human ... ARG1(383) , ARG2(384) ; mouse ... ARG1(11846) , ARG2(11847) ; rat ... ARG2(29215) , Arg1(29221)

설명

일반 설명

Arginase is a manganese-containing enzyme that catalyzes the conversion of arginine to urea and ornithine. Two isoforms of arginase are present in most mammals which differ in their tissue distribution and subcellular localization. Arginase I is a cytoplasmic protein predominantly expressed in the liver where it catalyzes the fifth and final step of the Urea Cycle. Arginase II is a mitochondrial protein with broader tissue distribution whose function may include nitric oxide and polyamine metabolism. Decreased activity or expression of Arginase I results in the autosomal recessive disorder hyperarginemia. Increased serum Arginase activity is implicated in hepatic injury and in certain pathological conditions such as cancer. Arginase also participates in multiple inflammatory reactions in the immune system, such as macrophage-mediated cytotoxicity.

애플리케이션

Arginase Activity Assay Kit has been used to assess the activity of arginase.

특징 및 장점

Compatible with high-throughput handling systems.

적합성

Suitable for the detection of arginase activity in enzyme preparations, serum, plasma, tissue culture, and similar samples. Suitable for studying the effects of drugs on arginase activity.

원리

In this assay, arginase catalyzes the conversion of arginine to urea and ornithine. The urea produced specifically reacts with the substrate to generate a colored product, proportional to the arginase activity present.

안전성 정보

• 픽토그램: GHS08,GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H290,H314,H360FD,H412
• 예방조치 성명서: P202 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 3 - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1A
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable