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추천 제품
생물학적 소스
synthetic (organic)
분석
≥98% (HPLC)
양식
powder
mp
203-204 °C
solubility
acetone: 50 mg/mL, clear to slightly hazy, yellow
SMILES string
O=C(O)C1=CC=CN=C1NC2=CC(C(F)(F)F)=CC=C2
InChI
1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)
InChI key
JZFPYUNJRRFVQU-UHFFFAOYSA-N
유전자 정보
human ... PTGS1(5742)
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애플리케이션
Niflumic acid has been used:
- as a chloride channel blocker in mouse olfactory epithelium for odor-induced electroolfactograms (EOGs) measurements[1], to test its analgesic effect on rat dorsal root ganglion neurons post γ-aminobutyric acid induction[2]
- as a calcium-activated chloride channel (CaCC) inhibitor in C2C12 myoblasts and also to test its effect on volume-regulated anion channel (VRAC)[3]
- as an inhibitor of voltage-dependent potassium channel in human embryonic kidney (HEK 293) phoenix cells[4]
생화학적/생리학적 작용
Niflumic acid (NFA), a γ-aminobutyric acid type A receptor (GABAARs) antagonist [2] is a non-steroidal anti-inflammatory drug (NSAID) and it belongs to the fenamate class.[4] It is also a blocker of chloride ion channel[2] and a calcium-activated chloride channel (CaCC) inhibitor.[3] NFA possesses anti-inflammatory property and is useful in treating rheumatic disorders.[4] It is also an inhibitor of N-methyl-D-aspartate receptor[4] and glycine receptor.[5] NFA also inhibits enzymes associated with the prostaglandins synthesis.[5]
Selective cyclooxygenase-2 (COX-2) inhibitor.
특징 및 장점
This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
개인 보호 장비
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
이미 열람한 고객
Michele Dibattista et al.
The Journal of general physiology, 140(1), 3-15 (2012-06-27)
The rodent vomeronasal organ plays a crucial role in several social behaviors. Detection of pheromones or other emitted signaling molecules occurs in the dendritic microvilli of vomeronasal sensory neurons, where the binding of molecules to vomeronasal receptors leads to the
Galyna Maleeva et al.
Frontiers in molecular neuroscience, 10, 125-125 (2017-06-01)
Niflumic acid (NFA) is a member of the fenamate class of nonsteroidal anti-inflammatory drugs. This compound and its derivatives are used worldwide clinically for the relief of chronic and acute pain. NFA is also a commonly used blocker of voltage-gated
Franziska Neureither et al.
Physiological reports, 5(15) (2017-08-09)
Many animals follow odor trails to find food, nesting sites, or mates, and they require only faint olfactory cues to do so. The performance of a tracking dog, for instance, poses the question on how the animal is able to
Juraj Rievaj et al.
Pflugers Archiv : European journal of physiology, 463(3), 497-509 (2011-12-16)
Protease-activated receptor 2 (PAR-2) is a G protein-coupled receptor possibly involved in the pathogenesis of asthma. PAR-2 also modulates ion transport in cultured epithelial cells, but these effects in native airways are controversial. The influence of allergic inflammation on PAR-2-induced
Luis Alvarez et al.
The Journal of cell biology, 196(5), 653-663 (2012-03-01)
During chemotaxis and phototaxis, sperm, algae, marine zooplankton, and other microswimmers move on helical paths or drifting circles by rhythmically bending cell protrusions called motile cilia or flagella. Sperm of marine invertebrates navigate in a chemoattractant gradient by adjusting the
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