P0884

(±)-Propranolol hydrochloride

≥99% (TLC), powder, β-adrenoceptor antagonist

• 동의어(들): (±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride, DL-Propranolol hydrochloride
• 실험식(Hill 표기법): C₁₆H₂₁NO₂ · HCl
• CAS Number: 318-98-9
• Molecular Weight: 295.80
• Beilstein: 4164259
• EC Number: 206-268-7
• MDL number: MFCD00012558
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277796
• NACRES: NA.77

속성

• 제품명: (±)-Propranolol hydrochloride, ≥99% (TLC), powder
• Quality Level: 200
• 분석: ≥99% (TLC)
• 양식: powder
• 색상: white
• solubility: ethanol: 10 mg/mL; DMSO: <14.5 mg/mL; H₂O: 50 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
• 주관자: AstraZeneca
• 저장 온도: 2-8°C
• SMILES string: Cl.CC(C)NCC(O)COc1cccc2ccccc12
• InChI: 1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
• InChI key: ZMRUPTIKESYGQW-UHFFFAOYSA-N
• 유전자 정보: human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

설명

일반 설명

Propranolol hydrochloride is easily soluble in ethanol and water.

dissolve with heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.

애플리케이션

(±)-Propranolol hydrochloride has been used:

• to determine whether autonomic nervous system mediated the promotive effect on skin microcirculation in rat
• as a non-selective β- receptor blocker to reduce the arrhythmogenic events
• to study its effect on oxygen-induced retinopathy in mice

생화학적/생리학적 작용

Propranolol hydrochloride is a β-adrenoceptor antagonist. Its action at β2 receptor results in bronchoconstriction. Due to its lipophilic nature, propranolol can penetrate to the central nervous system and has a negative effect. It serves as a 5-HT₁/5-HT₂ serotonin receptor antagonist. Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

주의사항

Shelf-life of the solid is at least four years if stored protected from the uptake of moisture.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 + P330 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves