Q1125

Quinine hydrochloride dihydrate

99-101% (titration), potassium channel blocker

• 실험식(Hill 표기법): C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• CAS Number: 6119-47-7
• Molecular Weight: 396.91
• EC Number: 205-001-1
• MDL number: MFCD00078498
• UNSPSC 코드: 12352210
• PubChem Substance ID: 57654577
• NACRES: NA.77

속성

• 제품명: Quinine hydrochloride dihydrate,
• Quality Level: 200
• solubility: H₂O: 0.25/5 g/mL, clear, colorless
• 항생제 활성 스펙트럼: parasites
• 동작 모드: enzyme | inhibits
• SMILES string: O.Cl.[H][C@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@H](O)c3ccnc4ccc(OC)cc34
• InChI: 1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19-,20+;;/m0../s1
• InChI key: SGVZDMWHXVXUBY-HZQSTTLBSA-N

설명

일반 설명

Quinine is derived from the stem of cinchona (quina-quina) tree.[1] It is an alkaloid having various applications in the field of medicine.[2] Quinine is a basic compound with aryl amino alcohol group.[1]

애플리케이션

Quinine hydrochloride dihydrate has been used in Drosophila larval behavioral assay.[3] It has also been used in taste preference analysis among rats.[4]

생화학적/생리학적 작용

Potassium channel blocker

Quinine is widely used in the treatment of malaria. It possesses erythrocytic and gametocytocidal action against Plasmodium sp. It also serves as an analgesic drug. Upon administration, quinine is present mostly bound to α-1 acid glycoprotein in the body fluids. Quinine has the ability to cross the placenta and the blood brain barrier. It has a half-life of 11-18 hours. Tinnitus, hearing defects, nausea and headache are some of its side effects.[1]

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H317,H334
• 예방조치 성명서: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves