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Q1250

Sigma-Aldrich

Quinine hemisulfate salt monohydrate

synthetic, ≥90% (HPLC)

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Synonym(s):
Quinine sulfate (2:1) (salt) dihydrate
Empirical Formula (Hill Notation):
C20H24N2O2 · 0.5H2O4S · H2O
CAS Number:
Molecular Weight:
391.47
Beilstein/REAXYS Number:
6113937
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic

Quality Level

assay

≥90% (HPLC)

mp

~225 °C (dec.) (lit.)

solubility

H2O: slightly soluble 1.2 mg/mL
ethanol: 8 mg/mL

antibiotic activity spectrum

parasites

mode of action

enzyme | inhibits

originator

Bayer

SMILES string

O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1

InChI key

ZHNFLHYOFXQIOW-LPYZJUEESA-N

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Application

Quinine hemisulfate salt monohydrate has been used as a stimuli to evaluate its influence on sensory and cognitive factors.

Biochem/physiol Actions

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
Quinine has analgesic property.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Exclamation mark

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Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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