SML2160
R-568 hydrochloride
≥95% (HPLC)
동의어(들):
2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride (1:1), KRN 568 hydrochloride, NPS-R 568 hydrochloride, Norcalcin hydrochloride, R 568 hydrochloride, Tecalcet hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C18H22ClNO · HCl
CAS Number:
Molecular Weight:
340.29
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
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추천 제품
분석
≥95% (HPLC)
양식
powder
광학 활성
[α]/D +35 to +40°, c = 0.5 in chloroform-d
저장 조건
desiccated
색상
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
저장 온도
2-8°C
SMILES string
C[C@@H](NCCCC1=C(C=CC=C1)Cl)C2=CC=CC(OC)=C2.Cl
InChI
1S/C18H22ClNO.ClH/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19;/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3;1H/t14-;/m1./s1
InChI key
YJXUXANREVNZLH-PFEQFJNWSA-N
생화학적/생리학적 작용
Calcium-sensing receptor (CaSR) allosteric agonist; calcimimetic
R-568 is a positive allosteric modulator of the calcium-sensing receptor (CaSR), increasing the sensitivity to activation by extracellular Ca2+. In rats, orally administered R-568 decreases plasma levels of PTH and Ca2+ and, at higher doses, increases plasma levels of calcitonin.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Jenny Ying Lin Lu et al.
The Journal of pharmacology and experimental therapeutics, 331(3), 775-786 (2009-09-18)
Over 257 mutations in the human calcium-sensing receptor (hCaSR) gene have been reported. Heterozygous inactivating mutations can result in familial hypocalciuric hypercalcemia (FHH), whereas homozygous inactivating mutations can cause life-threatening neonatal severe hyperparathyroidism (NSHPT). Activating mutations in the hCaSR can
Fanny Bery et al.
Cancers, 12(4) (2020-04-08)
The mechanisms underlying neuroendocrine (NE) differentiation in prostate cancer (PCa) remain mostly uncharacterized. Since a deregulated calcium homeostasis has been reported in neuroendocrine prostate cancer (NEPC), we explored herein the link between NE differentiation and the calcium-sensing receptor (CaSR). CaSR
Asuka Masumoto et al.
Journal of atherosclerosis and thrombosis, 24(7), 716-724 (2016-11-15)
Vascular calcification (VC) is a risk factor of cardiovascular and all-cause mortality in patients with chronic kidney disease (CKD). CKD-mineral and bone metabolism disorder is an important problem in patients with renal failure. Abnormal levels of serum phosphate and calcium
Abhishek Aggarwal et al.
Biochimica et biophysica acta, 1853(9), 2158-2167 (2015-02-24)
The inverse correlation between dietary calcium intake and the risk of colorectal cancer (CRC) is well known, but poorly understood. Expression of the calcium-sensing receptor (CaSR), a calcium-binding G protein-coupled receptor is downregulated in CRC leading us to hypothesize that
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