H9523

Serotonin hydrochloride

≥98%, powder, neurotransmitter

• Synonym(s): 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride
• Empirical Formula (Hill Notation): C₁₀H₁₂N₂O · HCl
• CAS Number: 153-98-0
• Molecular Weight: 212.68
• Beilstein/REAXYS Number: 3570963
• MDL number: MFCD00012686
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278124
• NACRES: NA.77

Properties

• product name: Serotonin hydrochloride, powder
• assay: ≥98%
• form: powder
• color: white to off-white
• mp: 149-154 °C (lit.)
• solubility: H₂O: 17 mg/mL; 0.1 M HCl: 22 mg/mL; ethanol: 5.3 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl[H].NCCc1c[nH]c2ccc(O)cc12
• InChI: 1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
• InChI key: MDIGAZPGKJFIAH-UHFFFAOYSA-N
• Gene Information: human ... HTR3A(3359)

Description

General description

Serotonin is a ubiquitous molecule found in all animals. It shows diverse effects in the central and peripheral nervous system (CAN/PNS). Serotonin acts as a hormone and as a mitogen. It is produced in the axon terminal present in the brain. Action potential induces the release of serotonin that diffuses across the synapse to turn on the post-synaptic receptors. Serotonin plays a crucialrole in development, respiration, thermoregulation, endocrine, cardiovascular, and gastrointestinal functions. It also plays a role in sensory perceptional behaviors such as the sleep-wake cycle, sex, mood, memory, aggression, pain sensitivity, learning, and cognition. Serotonin impacts several psychiatric disorders such as schizophrenia, anorexia nervosa, depression, and a range of anxiety disorders such as obsessive-compulsive disorder, panic attacks, and social phobia. Variations in serotonin levels are associated withimpulse-related disorders or personalities like substance abuse, gambling, attention deficit disorder, obsessive-control, and aggression.

Application

Serotonin hydrochloride hasbeen used: to study the mechanisms of 5-hydroxytryptamine receptor antagonistsregulate fibrosis in liver spheroids, to study its effects on theextracellular-related-kinase (ERK) phosphorylation in human embryonic kidneycells, in transwell assay, wound healing assay and tumor allograft assay incolon carcinoma cell line

Biochem/physiol Actions

Neurotransmitter.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Solutions should be freshly prepared.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H361
• pcodes: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Repr. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves