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H9523

Sigma-Aldrich

Serotonin hydrochloride

powder

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Synonym(s):
3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride
Empirical Formula (Hill Notation):
C10H12N2O · HCl
CAS Number:
Molecular Weight:
212.68
Beilstein:
3570963
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Assay

≥98%

Quality Level

form

powder

color

white to off-white

mp

149-154 °C (lit.)

solubility

H2O: 17 mg/mL
0.1 M HCl: 22 mg/mL
ethanol: 5.3 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].NCCc1c[nH]c2ccc(O)cc12

InChI

1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H

InChI key

MDIGAZPGKJFIAH-UHFFFAOYSA-N

Gene Information

human ... HTR3A(3359)

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1 of 4

This Item
H7752M6628SML0640
form

powder

form

powder

form

crystalline

form

powder

color

white to off-white

color

white to off-white

color

-

color

white to brown

solubility

H2O: 17 mg/mL, 0.1 M HCl: 22 mg/mL, ethanol: 5.3 mg/mL

solubility

0.1 M HCl: soluble (Solutions should be freshly prepared.), 95% ethanol: very slightly soluble (Solutions should be freshly prepared.), absolute ethanol: insoluble

solubility

-

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

mp

149-154 °C (lit.)

mp

-

mp

245-250 °C (dec.) (lit.)

mp

-

Biochem/physiol Actions

Neurotransmitter.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Solutions should be freshly prepared.

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Articles

Serotonin (5-hydroxytryptamine) is principally found stored in three main cell types - i) serotonergic neurons in the CNS and in the intestinal myenteric plexus, ii) enterochromaffin cells in the mucosa of the gastrointestinal tract, and iii) in blood platelets. Metabolism of serotonin is carried out primarily by the outer mitochondrial membrane enzyme monoamine oxidase (MAO), which occurs as two molecular subtypes called MAO-A and MAO-B.

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