H7250

Histamine dihydrochloride

≥99% (TLC), powder, endogenous histamine receptor agonist

• Synonym(s): 2-(4-Imidazolyl)ethylamine dihydrochloride
• Empirical Formula (Hill Notation): C₅H₉N₃ · 2HCl
• CAS Number: 56-92-8
• Molecular Weight: 184.07
• Beilstein/REAXYS Number: 3624116
• EC Number: 200-298-4
• MDL number: MFCD00012703
• UNSPSC Code: 12352116
• eCl@ss: 32160406
• PubChem Substance ID: 24277777
• NACRES: NA.77

Properties

• product name: Histamine dihydrochloride, ≥99% (TLC), powder
• assay: ≥99% (TLC)
• form: powder
• color: white to off-white
• mp: 249-252 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: Cl[H].Cl[H].NCCc1c[nH]cn1
• InChI: 1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
• InChI key: PPZMYIBUHIPZOS-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269) , HRH2(3274)

Description

General description

Histamine dihydrochloride is a derivative of histamine. It prevents the formation of ROS (reactive oxygen species), which inhibits the activation of T cells and natural killer cells. Histamine dihydrochloride is implicated in tumor cell apoptosis. It prevents the relapse of acute myeloid leukemia in patients.

Application

Histamine dihydrochloride has been used:

• as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
• to determine its level in fish using HPLC (high performance liquid chromatography)
• to assess the tracheal response to antigens in guinea-pigs

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H315,H317,H319,H334,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves