H8502

Dopamine hydrochloride

≥98% (TLC), powder, neurotransmitter

• Synonym(s): 2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride, 3,4-Dihydroxyphenethylamine hydrochloride, 3-Hydroxytyramine hydrochloride, 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride
• Linear Formula: (HO)₂C₆H₃CH₂CH₂NH₂·HCl
• CAS Number: 62-31-7
• Molecular Weight: 189.64
• Beilstein/REAXYS Number: 3656720
• EC Number: 200-527-8
• MDL number: MFCD00012898
• UNSPSC Code: 12352116
• PubChem Substance ID: 24277897
• NACRES: NA.77

Properties

• product name: Dopamine hydrochloride,
• form: powder
• color: light tan
• mp: 248-250 °C (lit.)
• solubility: alcohol: 20 mg/mL; H₂O: soluble
• storage temp.: 2-8°C
• SMILES string: Cl[H].NCCc1ccc(O)c(O)c1
• InChI: 1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H
• InChI key: CTENFNNZBMHDDG-UHFFFAOYSA-N
• Gene Information: human ... ADRB1(153)

Description

General description

Dopamine (DA) works as a neurotransmitter in the central nervous system. It is a catecholamine made from the amino acid L-tyrosine. It also works as a hormone in the vesicles of the adrenal medulla, thereby controlling heart beat rate and blood pressure. The Absence of DA-containing neurons is associated with Parkinson’s disease.Dopamine is produced and released by the dopaminergic neurons in the substantia nigra that is in the central nervous system. It is involved in several activities such as movement, behaviour, learning, reward, punishment, dreaming, working, memory, mood, sleep, attention, and inhibition of prolactin production. Dopamine also acts as a precursor in the synthesis of catecholamines like epinephrine and norepinephrine. Increased levels of dopamine via the tuberoinfundibular pathway are associated with Schizophrenia, hallucinations, euphoria, and psychosis. A deficiency of dopamine and norepinephrine indicates the neurochemical basis for attention-deficit hyperactivity disorder (ADHD), a pediatric disorder.

Application

Dopamine hydrochloride has been used:

• to study dopamine-mediated transient modulation of the physiological responses in white leg shrimp, Litopenaeus vannamei.
• to study dopamine-mediated changes in immunity susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.
• to study the molecular link between dopamine-induced oxidative stress and mHtt (mutant Huntingtin) toxicity in relation to the activation of the autophagy pathway in an ‘in vitro’ model of parkinsonian Huntington′s Disease.
• as a substrate of the prophenoloxidase (PPO) cascade reaction in the anti-microbial assay targeting methicillin-resistant staphylococcus aureus (MRSA) in the biofilm phase.
• added exogenously to the culture medium to study its effect on H. contortus female worms.

Features and Benefits

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Caution

Light sensitive

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves