추천 제품
생물학적 소스
mouse
재조합
expressed in CHO cells
태그
FLAG® tagged
분석
>95% (SDS-PAGE)
양식
lyophilized
분자량
~85 kDa
포장
pkg of 10 μg
저장 조건
avoid repeated freeze/thaw cycles
불순물
<0.1 EU/μg endotoxin, tested
색상
white
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
mouse ... Postn(50706)
일반 설명
Periostin (POSTN) is also called as osteoblast-specific factor 2. It is a matricellular protein, located in the alveolar walls. This gene is located on human chromosome 13q13.
Periostin was originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein (BMP-2). Abnormal expression of periostin is also linked to angiogenesis and metastasis in epithelial tumors.
생화학적/생리학적 작용
Periostin (POSTN) participates in collagen fibrillogenesis. It plays a major role in the development of scar after traumatic spinal cord injury (SCI). Periostin controls the activities of fibrocyte to stimulate myofibroblast differentiation and lung fibrosis. It modulates the amount of collagen in tissue. Periostin also participates in the assembly of the extracellular matrix (ECM) architecture.
물리적 형태
Lyophilized from PBS.
재구성
Reconstitute with 100 μL deionized water.
기타 정보
Mouse periostin (aa 24-783) (isoform 5) is fused at the C-terminus to a FLAG®-tag.
법적 정보
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Nicolette M Jeanblanc et al.
Clinica chimica acta; international journal of clinical chemistry, 464, 228-235 (2016-10-19)
Periostin is being investigated as a potential biomarker for T-helper-2 (Th2)-driven asthma or eosinophilic inflammation and may help to identify patients more likely to benefit from interleukin-13-targeted treatments. We report the development and analytic performance of the investigational use only
Teresa Cobo et al.
PloS one, 11(1), e0147837-e0147837 (2016-01-26)
Periostin is an extracellular matrix protein highly expressed in collagen-rich tissues subjected to continuous mechanical stress. Functionally, periostin is involved in tissue remodeling and its altered function is associated to numerous pathological processes. In orthodontics, periostin plays key roles in
A K Devrim et al.
Bratislavske lekarske listy, 118(11), 705-709 (2017-12-09)
Although the molecular mechanism of cardiac healing is not fully understood, myocardial infarction is one of the most usual diagnoses in hospitalized patients in industrialized nations while periostin has been recently suggested to have a potential in tissue repairing following
Jin Ho Hwang et al.
American journal of nephrology, 46(6), 501-517 (2017-12-22)
Periostin is responsible for tissue regeneration, fibrosis, and wound healing via its interaction with integrin. Recently, the role of periostin has been shown to contribute to fibrosis in chronic kidney disease. We investigated the role of periostin and the effect
Shoichiro Ohta et al.
PloS one, 12(3), e0174547-e0174547 (2017-03-30)
The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF is important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker for IPF. Our aim was
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