추천 제품
생물학적 소스
synthetic (organic)
Quality Level
분석
≥98% (TLC)
양식
powder
기술
toxicology assay: suitable
저장 온도
2-8°C
SMILES string
CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InChI
1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
InChI key
GKCBAIGFKIBETG-UHFFFAOYSA-N
유전자 정보
human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
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관련 카테고리
일반 설명
Tetracaine belongs to the amino-ester class and has a pKa of 8.46.
애플리케이션
Tetracaine can be used as a research tool for studying E-C coupling in both skeletal as well as cardiac muscle. The product is a local anaesthetic drug used for studying the impact of numerous drugs on Tumour-necrosis-factor (TNF)-mediated cytotoxicity as well as TNF-induced arachidonic acid release.
Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats.
Topical ophthalmic anesthetic; used for spinal anesthesia
생화학적/생리학적 작용
Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.
Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis.
Tetracaine blocks intracellular sodium channels. It mediates phosphorylation of eukaryotic initiation factor 2 (eIF2 α) via translational inhibition of P-body formation.
제조 메모
250 mg of tetracaine dissolves in 5 ml of EtOH to yield a clear, colorless solution. The product is also soluble in chloroform and ether at a ratio of 1:2 and in ethanol at 1:5. It is very slightly soluble in water.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
이미 열람한 고객
Insect morphogenetic hormones and developmental mechanisms in the nematode, Nematospiroides dubius.
R D Dennis
Comparative biochemistry and physiology. A, Comparative physiology, 53(1), 53-56 (1976-01-01)
Pharmacological considerations for Regional Anesthesia
Principles and Practice of Opthalmic Anesthesia (2018)
Tetracaine, a local anesthetic, preferentially induces translational inhibition with processing body formation rather than phosphorylation of eIF2alpha in yeast
Araki T, et al.
Current Genetics, 61(1), 43-53 (2015)
Lactobacillus gasseri in the upper small intestine impacts an ACSL3-dependent fatty acid-sensing pathway regulating whole-body glucose homeostasis
Bauer PV, et al.
Cell Metabolism, 27(3), 572-587 (2018)
H Thomas Lee et al.
American journal of nephrology, 23(3), 129-139 (2003-02-15)
Renal cell apoptosis contributes significantly to the pathogenesis of acute renal failure. Local anesthetics induce apoptosis in neuronal and lymphocytic cell lines. We examined the effects of chronic (48 h) local anesthetic treatment (lidocaine, bupivacaine and tetracaine) on human proximal
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