추천 제품
제품명
Discovery® Cyano HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4 mm
material
stainless steel column
Quality Level
Agency
suitable for USP L10
제품 라인
Discovery®
특징
endcapped
제조업체/상표
Discovery®
포장
1 ea of
라벨링 범위
4.5% Carbon loading
파라미터
≤70 °C temp. range
400 bar pressure (5801 psi)
기술
HPLC: suitable
LC/MS: suitable
길이 × I.D.
25 cm × 4 mm
표면적
200 m2/g
표면 범위
3.5 μmol/m2
불순물
<10 ppm metals
Matrix
silica gel, high purity, spherical base material
fully porous particle
기질 활성군
cyano phase
입자 크기
5 μm
공극 크기
180 Å
작동 pH 범위
2-8
응용 분야
food and beverages
분리 기술
hydrophilic interaction (HILIC)
normal phase
reversed phase
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특징 및 장점
- Low hydrophobicity for rapid elution of hydrophobic analytes
- Excellent peak shape and retention of strongly basic analytes
- Retention of polar analytes
- Unique selectivity
- Significantly less retention than C18 (typically requires lower % organic mobile phase)
- Stable, low-bleed LC-MS separations
- Compatible with highly aqueous organic phases
법적 정보
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
Srdan Verstovsek et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)
The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no
Christophe Morisseau et al.
Analytical biochemistry, 414(1), 154-162 (2011-03-05)
The microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics. In addition, it has a potential role in sexual development and bile acid transport, and it is associated with a number of diseases such as
K Umekawa et al.
Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other
T A Verdoorn et al.
European journal of pharmacology, 269(1), 43-49 (1994-09-15)
The diversity of neuronal glutamate receptors continues to increase with the discovery of multiple subunits and subunit families. The significance of this potential receptor heterogeneity is unknown because pharmacological tools that could clearly distinguish between different structural isoforms have not
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