추천 제품
product name
Discovery® Cyano HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4 mm
material
stainless steel column
Quality Level
Agency
suitable for USP L10
제품 라인
Discovery®
특징
endcapped
제조업체/상표
Discovery®
포장
1 ea of
라벨링 범위
4.5% Carbon loading
파라미터
≤70 °C temp. range
400 bar pressure (5801 psi)
기술
HPLC: suitable
LC/MS: suitable
길이 × I.D.
25 cm × 4 mm
표면적
200 m2/g
표면 범위
3.5 μmol/m2
불순물
<10 ppm metals
기질
silica gel, high purity, spherical base material
fully porous particle
기질 활성군
cyano phase
입자 크기
5 μm
공극 크기
180 Å
operating pH range
2-8
응용 분야
food and beverages
분리 기술
hydrophilic interaction (HILIC)
normal phase
reversed phase
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특징 및 장점
- Low hydrophobicity for rapid elution of hydrophobic analytes
- Excellent peak shape and retention of strongly basic analytes
- Retention of polar analytes
- Unique selectivity
- Significantly less retention than C18 (typically requires lower % organic mobile phase)
- Stable, low-bleed LC-MS separations
- Compatible with highly aqueous organic phases
법적 정보
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at
Aaron D Milstein et al.
Trends in pharmacological sciences, 29(7), 333-339 (2008-06-03)
Presynaptic glutamate release elicits brief waves of membrane depolarization in neurons by activating AMPA receptors. Depending on its precise size and shape, current through AMPA receptors gates downstream processes like NMDA receptor activation and action potential generation. Over a decade
Aleem Gangjee et al.
Journal of medicinal chemistry, 53(22), 8116-8128 (2010-10-27)
Two classes of molecules were designed and synthesized based on a 6-CH(3) cyclopenta[d]pyrimidine scaffold and a pyrrolo[2,3-d]pyrimidine scaffold. The pyrrolo[2,3-d]pyrimidines were synthesized by reacting ethyl 2-cyano-4,4-diethoxybutanoate and acetamidine, which in turn was chlorinated and reacted with the appropriate anilines to
Xuqing Zhang et al.
Journal of medicinal chemistry, 50(16), 3857-3869 (2007-07-20)
A novel series of pyrazolines 2 have been designed, synthesized, and evaluated by in vivo screening as tissue-selective androgen receptor modulators (SARMs). Structure-activity relationships (SAR) were investigated at the R1 to R6 positions as well as the core pyrazoline ring
Ubaldo E Martinez-Outschoorn et al.
Cell cycle (Georgetown, Tex.), 11(21), 3956-3963 (2012-10-23)
We have previously suggested that ketone body metabolism is critical for tumor progression and metastasis. Here, using a co-culture system employing human breast cancer cells (MCF7) and hTERT-immortalized fibroblasts, we provide new evidence to directly support this hypothesis. More specifically
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