MilliporeSigma

ABCG2

ATP-binding cassette, sub-family G (WHITE), member 2

Synonyms:
ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1
Species:
UniProtKB ID:
Gene ID:
  • Human(9429) Summary: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
  • Mouse(26357) ATP-binding cassette, sub-family G (WHITE), member 2
  • Rat(312382) ATP-binding cassette, subfamily G (WHITE), member 2
  • domestic guinea pig(100723442) ATP-binding cassette, sub-family G (WHITE), member 2
  • domestic cat(101094017) ATP-binding cassette, sub-family G (WHITE), member 2
  • chicken(423767) ATP-binding cassette, sub-family G (WHITE), member 2
  • dog(478472) ATP-binding cassette, sub-family G (WHITE), member 2
  • Horse(100034164) ATP-binding cassette, sub-family G (WHITE), member 2
  • cow(536203) ATP-binding cassette, sub-family G (WHITE), member 2
  • sheep(780508) ATP-binding cassette, sub-family G (WHITE), member 2
  • Domestic Rabbit(100008640) ATP-binding cassette, sub-family G (WHITE), member 2
  • Goat(100860857) ATP-binding cassette, sub-family G (WHITE), member 2

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ABCG2 antibody produced in mouse, clone 1G1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-ABCG2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-BCRP Antibody, clone BXP-34, culture supernatant, clone BXP-34, Chemicon®,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
Anti-ABCG2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-BCRP (ABCG2) Antibody, clone 10K5 , ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunohistochemistry

western blot

Cell Lines

Product Number
Description
Species
HepaRG Cells BCRP (-/-), one vial,
Species
human
Canine MDR1 Knockout, Human BCRP/OATP2B1 double Knockin MDCKII Cells, ,
Species
human
Canine MDR1 Knockout, Human BCRP Knockin MDCKII Cells, ,
Species
human
SB-cyBcrp-HEK293, ,
Species
BCRP Knockout Caco-2 Cells, one vial,
Species
human

Proteins

Product Number
Description
Species
SB-BCRP-M-PREDEASY-ATPase kit, membrane based kit for Human BCRP ATPase Transport Assays,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Abcg2,
Species
mouse
MISSION® esiRNA, targeting human ABCG2,
Species
human