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BCRP Knockout Caco-2 Cells

one vial

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C2BBe1 Cells BCRP (-/-/-/-)

biological source

human male colorectal tissue (Source disease: adenocarcinoma)

Quality Level




drug transporter assay: suitable
permeability assay: suitable

OMIM accession no.



storage temp.


Gene Information

human ... ABCG2(9429)

General description

The C2BBe1 cells, a subclone of Caco-2 cells, correspond to ATCC CRL-2102. The BCRP knockout C2BBe1 cells are adenocarcinoma, epithelial cells from a human caucasian male (aged 72 years) with functional knockout of the ABCG2 (BCRP) efflux transporter.

Features and Benefits

The Caco-2 subclone C2BBe1 cells are ideal for transporter analysis as they express multiple transporters, are human derived, and grow in a homogenous monolayer that forms tight junctions necessary for efflux ratio analysis. Other benefits include:
  • A functional knockout of the BCRP gene eliminates the reliance on chemical inhibitors to determine if a compound is an BCRP substrate
  • The vial format enables the BCRP knockout cells to be included in standard drug transporter protocols
  • Human assay with no interference from animal inhibitors
  • Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality


RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Kit Components Also Available Separately

Product No.

  • MTOX1002BCRP Knockout Caco-2 Cells, one vial 1 vialSDS

Storage Class

10 - Combustible liquids




Not applicable


Not applicable

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