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Merck

ABCG2

ATP-binding cassette, sub-family G (WHITE), member 2

Synonymes:
ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1
Espèce(s):
Human ABCG2 (9429), Mouse Abcg2 (26357), Rat Abcg2 (312382), domestic guinea pig Abcg2 (100723442), domestic cat ABCG2 (101094017), chicken ABCG2 (423767), dog ABCG2 (478472), Horse ABCG2 (100034164), cow ABCG2 (536203), sheep ABCG2 (780508) ...Plus
ID UniProtKB:
Q9UNQ0, A0A1W3, A8K1T5, O95374, Q53ZQ1, Q569L4, Q5YLG4, Q86V64
ID du gène:
  • Human(9429) Summary: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
  • Mouse(26357) ATP-binding cassette, sub-family G (WHITE), member 2
  • Rat(312382) ATP-binding cassette, subfamily G (WHITE), member 2
  • domestic guinea pig(100723442) ATP-binding cassette, sub-family G (WHITE), member 2
  • domestic cat(101094017) ATP-binding cassette, sub-family G (WHITE), member 2
  • chicken(423767) ATP-binding cassette, sub-family G (WHITE), member 2
  • dog(478472) ATP-binding cassette, sub-family G (WHITE), member 2
  • Horse(100034164) ATP-binding cassette, sub-family G (WHITE), member 2
  • cow(536203) ATP-binding cassette, sub-family G (WHITE), member 2
  • sheep(780508) ATP-binding cassette, sub-family G (WHITE), member 2
  • Domestic Rabbit(100008640) ATP-binding cassette, sub-family G (WHITE), member 2
  • Goat(100860857) ATP-binding cassette, sub-family G (WHITE), member 2

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Antibodies

Numéro du produit
Description
Espèces réactives
Application
ZRB1217
Anti-BCRP (ABCG2) Antibody, clone 10K5 , ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, mouse
Application
immunocytochemistry
immunohistochemistry
western blot
MAB4145
Anti-BCRP Antibody, clone BXP-34, culture supernatant, clone BXP-34, Chemicon®,
Espèces réactives
human
Application
immunocytochemistry
immunohistochemistry
SAB5701106
Anti-ABCG2 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
western blot
SAB5700094
Anti-ABCG2 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
western blot
B7185
Anti-Breast Cancer Resistance Protein antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human, mouse
Application
immunohistochemistry
western blot

Cell Lines

Numéro du produit
Description
Espèce(s)
MTOX1302
Canine MDR1 Knockout, Human BCRP/OATP2B1 double Knockin MDCKII Cells, ,
Espèce(s)
human

esiRNA

Numéro du produit
Description
Espèce(s)
EHU012921
MISSION® esiRNA, targeting human ABCG2,
Espèce(s)
human
EMU090051
MISSION® esiRNA, targeting mouse Abcg2,
Espèce(s)
mouse