MilliporeSigma

GABRG2

gamma-aminobutyric acid (GABA) A receptor, gamma 2

Synonyms:
CAE2, ECA2, GEFSP3
Species:
UniProtKB ID:
Gene ID:
  • Human(2566) Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(14406) gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
  • Rat(29709) gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • Horse(100059571) gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • sheep(101118526) gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • Zebrafish(553402) gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • chicken(396289) gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • dog(489141) gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • domestic cat(100286791) gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • cow(282240) gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • domestic guinea pig(100723005) gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • naked mole-rat(101718598) gamma-aminobutyric acid (GABA) A receptor, gamma 2

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Small Molecule - Agonist

Product Number
Description
Species
Meprobamate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Oxazepam, ,
Species
human
Meprobamate, analytical standard,
Species
human
Meprobamate, United States Pharmacopeia (USP) Reference Standard,
Species
human
γ-Aminobutyric acid, ≥99%,
Species
human, rat

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Zolpidem solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Zaleplon, United States Pharmacopeia (USP) Reference Standard,
Species
human
Zaleplon solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Zolpidem for system suitability, CRS, European Pharmacopoeia (EP) Reference Standard,
Species
human
5α-Pregnan-3α-ol-11,20-dione, powder, ≥98% (TLC),
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Etiocholan-3α-ol-17-one, ,
Species
human, rat
Zolpidem, ≥98% (HPLC), solid,
Species
human, rat
Flumazenil, United States Pharmacopeia (USP) Reference Standard,
Species
human
Ganaxolone, solid, ≥98% (HPLC),
Species
human, mouse
Flunitrazepam, ,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop, Chemicon®, from rabbit,
Species Reactivity
rat
Application
immunoprecipitation (IP)
western blot
Anti-GABA(A) receptor subunit gamma-2 Antibody, serum, from rabbit,
Species Reactivity
human, rat
Application
western blot
Anti-GABRG2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, human, mouse, rat
Application
ELISA
western blot
Anti-GABA(A) receptor subunit gamma-2 Antibody, clone 10F10-C1-B8, clone 10F10-C1-B8, from mouse,
Species Reactivity
rat
Application
immunocytochemistry
western blot
Anti- GABAA Antibody γ2 Subunit, clone KC4-8A7, clone KC4-8A7, from mouse,
Species Reactivity
bovine, human, mouse, rat
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

western blot

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Etiocholan-3α-ol-17-one, ,
Species
human, rat
Ganaxolone, solid, ≥98% (HPLC),
Species
human, mouse
5α-Pregnan-3α-ol-20-one, solid,
Species
human, mouse, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GABRG2,
Species
human