MilliporeSigma

HRH1

histamine receptor H1

Synonyms:
H1-R, hisH1
Species:
UniProtKB ID:
Gene ID:
  • Human(3269) Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
  • Mouse(15465) histamine receptor H1
  • Rat(24448) histamine receptor H 1
  • naked mole-rat(101715481) histamine receptor H1
  • domestic cat(101088314) histamine receptor H1
  • domestic guinea pig(100135539) histamine receptor H1
  • chicken(100858928) histamine receptor H1
  • domestic guinea pig(100730517) histamine receptor H1
  • cow(281231) histamine receptor H1
  • dog(403813) histamine receptor H1
  • Zebrafish(735302) histamine receptor H1
  • Horse(100034110) histamine receptor H1
  • sheep(101121717) histamine receptor H1

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Small Molecule - Agonist

Product Number
Description
Species
Histamine, analytical standard,
Species
human
Histamine, European Pharmacopoeia (EP) Reference Standard,
Species
human
Histamine dihydrochloride, ≥99.0% (AT),
Species
human
Histamine dihydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Histamine dihydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Methapyrilene HCl, analytical standard,
Species
human
Chlorpheniramine Maleate, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Clemastine fumarate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Chlorphenamine maleate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Diphenhydramine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-HRH1 antibody produced in mouse, clone 3D1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay
Anti-Histamine Receptor 1 Antibody, CT, Chemicon®, from rabbit,
Species Reactivity
bovine, mouse, rat
Application
ELISA
western blot

Small Molecule - Blocker

Product Number
Description
Species
Cinnarizine, European Pharmacopoeia (EP) Reference Standard,
Species
human
Cinnarizine, powder,
Species
human
Mianserin hydrochloride, ,
Species
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Species
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Ketotifen fumarate salt, ,
Species
human
D-Histidine monohydrochloride monohydrate, ≥98% (TLC),
Species
mouse, rat, human
L-Histidinol dihydrochloride, ≥98 (TLC),
Species
mouse, rat, human
Loratadine, ≥98% (HPLC), powder,
Species
rat, human
Histamine, ≥97.0%,
Species
human, rat

Small Molecule - Ligand

Product Number
Description
Species
Loratadine, ≥98% (HPLC), powder,
Species
rat, human
Cinnarizine, powder,
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
1-Methylhistamine dihydrochloride, ≥98% (TLC), powder,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
2-(2-Pyridyl)ethylamine, 95%,
Species
human
Haloperidol, powder,
Species
human, rat
Clozapine, ,
Species
human, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human HRH1,
Species
human
MISSION® esiRNA, targeting mouse Hrh1,
Species
mouse